Role of NRF2 and Sirtuin activators in COVID-19.
Clin Immunol
; 233: 108879, 2021 12.
Article
de En
| MEDLINE
| ID: mdl-34798239
ABSTRACT
COVID-19 is a pandemic requiring immediate solution for treatment because of its complex pathophysiology. Exploration of novel targets and thus treatment will be life savers which is the need of the hour. 2 host factors- TMPRSS2 and ACE2 are responsible for the way the virus will enter and replicate in the host. Also NRF2 is an important protein responsible for its anti-inflammatory role by multiple mechanisms of action like inhibition of NF-kB, suppression of pro-inflammatory genes, etc. NRF2 is deacetylated by Sirtuins and therefore both have a direct association. Absence of SIRT indicates inhibition of NRF2 expression and thus no anti-oxidative and anti-inflammatory protection for the cell. Therefore, we propose that NRF2 activators and/or SIRT activators can be evaluated to check their efficacy in ameliorating the symptoms of COVID-19.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Sirtuines
/
Facteur-2 apparenté à NF-E2
/
SARS-CoV-2
/
COVID-19
Limites:
Animals
/
Humans
Langue:
En
Journal:
Clin Immunol
Sujet du journal:
ALERGIA E IMUNOLOGIA
Année:
2021
Type de document:
Article
Pays d'affiliation:
Inde