HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio.

Liu, Shuohui; Koneru, Pratibha C; Li, Wen; Pathirage, Chathuri; Engelman, Alan N; Kvaratskhelia, Mamuka; Musier-Forsyth, Karin

Liu, Shuohui; Koneru, Pratibha C; Li, Wen; Pathirage, Chathuri; Engelman, Alan N; Kvaratskhelia, Mamuka; Musier-Forsyth, Karin.

Affiliation

Liu S; Department of Chemistry and Biochemistry, Centers for RNA Biology and Retroviral Research, The Ohio State University, Columbus, OH, USA.
Koneru PC; Division of Infectious Diseases, School of Medicine, University of Colorado, Aurora, CO, USA.
Li W; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Pathirage C; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Engelman AN; Department of Chemistry and Biochemistry, Centers for RNA Biology and Retroviral Research, The Ohio State University, Columbus, OH, USA.
Kvaratskhelia M; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Musier-Forsyth K; Department of Medicine, Harvard Medical School, Boston, MA, USA.

Retrovirology ; 18(1): 37, 2021 11 22.

Article de En | MEDLINE | ID: mdl-34809662

Sujet(s)
Mots clés

5'-UTR; ALLINI; HIV-1; Integrase; Nucleocapsid; RNA binding; RNA secondary structure; XL-SHAPE

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Virion / ARN viral / Infections à VIH / VIH-1 (Virus de l'Immunodéficience Humaine de type 1) / Intégrase du VIH Limites: Humans Langue: En Journal: Retrovirology Sujet du journal: VIROLOGIA Année: 2021 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: Royaume-Uni

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