Use of Monoclonal Antibodies Therapy for Treatment of Mild to Moderate COVID-19 in 4 Patients with Rheumatologic Disorders.
Med Sci Monit
; 27: e934267, 2021 Nov 25.
Article
de En
| MEDLINE
| ID: mdl-34819488
ABSTRACT
BACKGROUND The use of monoclonal antibodies therapy (MAT) in early mild to moderate Coronavirus disease 2019 (COVID-19) has gained importance in recent times. However, there is limited information on the safety and efficacy of MAT in treating COVID-19 in patients with underlying rheumatologic diseases. Patients with rheumatologic diseases are usually on long-term corticosteroids and immunosuppressive therapy, which increases their risk for progressing to more severe forms of COVID-19. We report a case series of 4 patients with rheumatologic diseases who were treated with MAT for COVID-19. MATERIAL AND METHODS A retrospective observational study was conducted in our institution on patients with underlying rheumatological disorders who received MAT as per the EUA protocol of the FDA. RESULTS Two of the 4 patients were on immunosuppresive therapy at the time of receiving MAT. They recovered from COVID-19 without any adverse outcomes. No flare of underlying rheumatologic disease was noted. CONCLUSIONS MAT was observed to be a safe and effective therapy in 4 patients with rheumatological illnesses and COVID-19 treated at our hospital.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Polyarthrite rhumatoïde
/
Anticorps monoclonaux humanisés
/
SARS-CoV-2
/
COVID-19
/
Traitements médicamenteux de la COVID-19
/
Immunothérapie
Type d'étude:
Guideline
/
Observational_studies
Limites:
Aged
/
Female
/
Humans
/
Middle aged
Langue:
En
Journal:
Med Sci Monit
Sujet du journal:
MEDICINA
Année:
2021
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique