Homogeneous antibody and CAR-T cells with improved effector functions targeting SSEA-4 glycan on pancreatic cancer.

Lin, Chih-Wei; Wang, Yu-Jen; Lai, Ting-Yen; Hsu, Tsui-Ling; Han, Shin-Ying; Wu, Han-Chung; Shen, Chia-Ning; Dang, Van; Chen, Ming-Wei; Chen, Lan-Bo; Wong, Chi-Huey

Lin, Chih-Wei; Wang, Yu-Jen; Lai, Ting-Yen; Hsu, Tsui-Ling; Han, Shin-Ying; Wu, Han-Chung; Shen, Chia-Ning; Dang, Van; Chen, Ming-Wei; Chen, Lan-Bo; Wong, Chi-Huey.

Affiliation

Lin CW; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
Wang YJ; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
Lai TY; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
Hsu TL; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.
Han SY; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
Wu HC; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
Shen CN; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
Dang V; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan.
Chen MW; Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan.
Chen LB; Department of Cell Biology, CHO Pharma USA, Inc., Woburn, MA 01801.
Wong CH; Department of Cell Biology, CHO Pharma USA, Inc., Woburn, MA 01801.

Proc Natl Acad Sci U S A ; 118(50)2021 12 14.

Article de En | MEDLINE | ID: mdl-34876527

Sujet(s)
Mots clés

CAR-T; SSEA-4 expression; homogeneous antibody; pancreatic cancer

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs du pancréas / Antigènes embryonnaires spécifiques de stade / Anticorps Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Proc Natl Acad Sci U S A Année: 2021 Type de document: Article Pays de publication: États-Unis d'Amérique

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