Perillaldehyde improves cognitive function in vivo and in vitro by inhibiting neuronal damage via blocking TRPM2/NMDAR pathway.

Qiu, Yue; Xue, Xian-Jun; Liu, Geng; Shen, Miao-Miao; Chao, Chun-Yan; Zhang, Jie; Guo, Ya-Qi; Niu, Qian-Qian; Yu, Ya-Nan; Song, Yu-Ting; Wang, Huan-Huan; Wang, Shuang-Xi; Chen, Yu-Jing; Jiang, Lin-Hua; Li, Peng; Yin, Ya-Ling

Qiu, Yue; Xue, Xian-Jun; Liu, Geng; Shen, Miao-Miao; Chao, Chun-Yan; Zhang, Jie; Guo, Ya-Qi; Niu, Qian-Qian; Yu, Ya-Nan; Song, Yu-Ting; Wang, Huan-Huan; Wang, Shuang-Xi; Chen, Yu-Jing; Jiang, Lin-Hua; Li, Peng; Yin, Ya-Ling.

Affiliation

Qiu Y; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China.
Xue XJ; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China.
Liu G; Puyang Oilfield General Hospital, Puyang, 457001, China.
Shen MM; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China.
Chao CY; The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, 453003, China.
Zhang J; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China.
Guo YQ; The People's Hospital of Anyang City, Anyang, 455001, China.
Niu QQ; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China.
Yu YN; Huang Huai University, Zhumadian, 463000, China.
Song YT; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China.
Wang HH; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China.
Wang SX; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China.
Chen YJ; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China.
Jiang LH; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China.
Li P; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China.
Yin YL; College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang, 453003, China.

Chin Med ; 16(1): 136, 2021 Dec 13.

Article de En | MEDLINE | ID: mdl-34903262

Mots clés

NMDAR pathway; Perillaldehyde; TRPM2; Vascular dementia

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: Chin Med Année: 2021 Type de document: Article Pays d'affiliation: Chine