Global Percentage of Asymptomatic SARS-CoV-2 Infections Among the Tested Population and Individuals With Confirmed COVID-19 Diagnosis: A Systematic Review and Meta-analysis.
JAMA Netw Open
; 4(12): e2137257, 2021 12 01.
Article
de En
| MEDLINE
| ID: mdl-34905008
ABSTRACT
Importance Asymptomatic infections are potential sources of transmission for COVID-19. Objective:
To evaluate the percentage of asymptomatic infections among individuals undergoing testing (tested population) and those with confirmed COVID-19 (confirmed population). Data Sources PubMed, EMBASE, and ScienceDirect were searched on February 4, 2021. Study Selection Cross-sectional studies, cohort studies, case series studies, and case series on transmission reporting the number of asymptomatic infections among the tested and confirmed COVID-19 populations that were published in Chinese or English were included. Data Extraction andSynthesis:
This meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Random-effects models were used to estimate the pooled percentage and its 95% CI. Three researchers performed the data extraction independently. Main Outcomes andMeasures:
The percentage of asymptomatic infections among the tested and confirmed populations.Results:
Ninety-five unique eligible studies were included, covering 29â¯776â¯306 individuals undergoing testing. The pooled percentage of asymptomatic infections among the tested population was 0.25% (95% CI, 0.23%-0.27%), which was higher in nursing home residents or staff (4.52% [95% CI, 4.15%-4.89%]), air or cruise travelers (2.02% [95% CI, 1.66%-2.38%]), and pregnant women (2.34% [95% CI, 1.89%-2.78%]). The pooled percentage of asymptomatic infections among the confirmed population was 40.50% (95% CI, 33.50%-47.50%), which was higher in pregnant women (54.11% [95% CI, 39.16%-69.05%]), air or cruise travelers (52.91% [95% CI, 36.08%-69.73%]), and nursing home residents or staff (47.53% [95% CI, 36.36%-58.70%]). Conclusions and Relevance In this meta-analysis of the percentage of asymptomatic SARS-CoV-2 infections among populations tested for and with confirmed COVID-19, the pooled percentage of asymptomatic infections was 0.25% among the tested population and 40.50% among the confirmed population. The high percentage of asymptomatic infections highlights the potential transmission risk of asymptomatic infections in communities.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Infections asymptomatiques
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SARS-CoV-2
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COVID-19
Type d'étude:
Diagnostic_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
/
Systematic_reviews
Limites:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
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Middle aged
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Pregnancy
Langue:
En
Journal:
JAMA Netw Open
Année:
2021
Type de document:
Article
Pays d'affiliation:
Chine