Emapalumab in primary haemophagocytic lymphohistiocytosis and the pathogenic role of interferon gamma: A pharmacometric model-based approach.

Jacqmin, Philippe; Laveille, Christian; Snoeck, Eric; Jordan, Michael B; Locatelli, Franco; Ballabio, Maria; de Min, Cristina

Jacqmin, Philippe; Laveille, Christian; Snoeck, Eric; Jordan, Michael B; Locatelli, Franco; Ballabio, Maria; de Min, Cristina.

Affiliation

Jacqmin P; MnS Modelling and Simulation, Dinant, Belgium.
Laveille C; Calvagone Sarl, Liergues, France.
Snoeck E; Luccio BV, Meerhout, Belgium.
Jordan MB; Divisions of Immunobiology and Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Locatelli F; University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ballabio M; Department of Pediatrics, Sapienza, University of Rome, Rome, Italy.
de Min C; Department of Pediatric Hematology-Oncology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

Br J Clin Pharmacol ; 88(5): 2128-2139, 2022 05.

Article de En | MEDLINE | ID: mdl-34935183

Sujet(s)
Mots clés

immunology - inflammation; immunology - monoclonal antibodies; paediatrics - children; pharmacodynamics - modelling and simulation; pharmacodynamics - pharmacokinetics-pharmacodynamics

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Interféron gamma / Lymphohistiocytose hémophagocytaire Type d'étude: Clinical_trials / Prognostic_studies Limites: Child, preschool / Humans Langue: En Journal: Br J Clin Pharmacol Année: 2022 Type de document: Article Pays d'affiliation: Belgique

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