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Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics.
Gerckens, Michael; Schorpp, Kenji; Pelizza, Francesco; Wögrath, Melanie; Reichau, Kora; Ma, Huilong; Dworsky, Armando-Marco; Sengupta, Arunima; Stoleriu, Mircea Gabriel; Heinzelmann, Katharina; Merl-Pham, Juliane; Irmler, Martin; Alsafadi, Hani N; Trenkenschuh, Eduard; Sarnova, Lenka; Jirouskova, Marketa; Frieß, Wolfgang; Hauck, Stefanie M; Beckers, Johannes; Kneidinger, Nikolaus; Behr, Jürgen; Hilgendorff, Anne; Hadian, Kamyar; Lindner, Michael; Königshoff, Melanie; Eickelberg, Oliver; Gregor, Martin; Plettenburg, Oliver; Yildirim, Ali Önder; Burgstaller, Gerald.
Affiliation
  • Gerckens M; Institute of Lung Biology and Disease (ILBD) and Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
  • Schorpp K; Assay Development and Screening Platform, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Pelizza F; Chemical and Process Engineering, Strathclyde University, Glasgow, Scotland, UK.
  • Wögrath M; Institute of Lung Biology and Disease (ILBD) and Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
  • Reichau K; CPC-M bioArchive, Helmholtz Zentrum München, Comprehensive Pneumology Center Munich DZL/CPC-M, Munich, Germany.
  • Ma H; Institute of Medicinal Chemistry, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
  • Dworsky AM; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Hannover, Germany.
  • Sengupta A; Institute of Medicinal Chemistry, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
  • Stoleriu MG; Leibniz Universität Hannover, Institute of Organic Chemistry and Center for Biomolecular Drug Research (BMWZ), Hannover, Germany.
  • Heinzelmann K; Institute of Lung Biology and Disease (ILBD) and Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
  • Merl-Pham J; CPC-M bioArchive, Helmholtz Zentrum München, Comprehensive Pneumology Center Munich DZL/CPC-M, Munich, Germany.
  • Irmler M; Institute of Lung Biology and Disease (ILBD) and Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
  • Alsafadi HN; Institute of Lung Biology and Disease (ILBD) and Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
  • Trenkenschuh E; CPC-M bioArchive, Helmholtz Zentrum München, Comprehensive Pneumology Center Munich DZL/CPC-M, Munich, Germany.
  • Sarnova L; Asklepios Fachkliniken Munich-Gauting, Munich, Germany.
  • Jirouskova M; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Frieß W; Comprehensive Pneumology Center (CPC), Research Unit Lung Repair and Regeneration, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
  • Hauck SM; Research Unit Protein Science, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.
  • Beckers J; Institute of Experimental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
  • Kneidinger N; CPC-M bioArchive, Helmholtz Zentrum München, Comprehensive Pneumology Center Munich DZL/CPC-M, Munich, Germany.
  • Behr J; Comprehensive Pneumology Center (CPC), Research Unit Lung Repair and Regeneration, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.
  • Hilgendorff A; Wallenberg Center for Molecular Medicine (WCMM), Department of Experimental Medical Sciences, Lund University, Lund, Sweden.
  • Hadian K; Department of Pharmacy-Center for Drug Research, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximillians University of Munich, Munich, Germany.
  • Lindner M; Laboratory of Integrative Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
  • Königshoff M; Laboratory of Integrative Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
  • Eickelberg O; Department of Pharmacy-Center for Drug Research, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximillians University of Munich, Munich, Germany.
  • Gregor M; Research Unit Protein Science, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.
  • Plettenburg O; Institute of Experimental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
  • Yildirim AÖ; German Center for Diabetes Research (DZD e.V.), 85764 Neuherberg, Germany.
  • Burgstaller G; Chair of Experimental Genetics, Technische Universität München, 85354 Freising, Germany.
Sci Adv ; 7(52): eabb3673, 2021 Dec 24.
Article de En | MEDLINE | ID: mdl-34936468
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Type d'étude: Diagnostic_studies / Screening_studies Langue: En Journal: Sci Adv Année: 2021 Type de document: Article Pays d'affiliation: Allemagne Pays de publication: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Type d'étude: Diagnostic_studies / Screening_studies Langue: En Journal: Sci Adv Année: 2021 Type de document: Article Pays d'affiliation: Allemagne Pays de publication: États-Unis d'Amérique