Antibody-drug Conjugate PCMC1D3-Duocarmycin SA as a Novel Therapeutic Entity for Targeted Treatment of Cancers Aberrantly Expressing MET Receptor Tyrosine Kinase.

Hudson, Rachel; Yao, Hang-Ping; Suthe, Sreedhar Reddy; Patel, Dhavalkumar; Wang, Ming-Hai

Hudson, Rachel; Yao, Hang-Ping; Suthe, Sreedhar Reddy; Patel, Dhavalkumar; Wang, Ming-Hai.

Affiliation

Hudson R; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases and National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yao HP; Department of Pharmaceutical Sciences, Pharmaceutical Research Core and Cancer Biology Research Center, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX, USA.
Suthe SR; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases and National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Patel D; Department of Pharmaceutical Sciences, Pharmaceutical Research Core and Cancer Biology Research Center, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX, USA.
Wang MH; Department of Pharmaceutical Sciences, Pharmaceutical Research Core and Cancer Biology Research Center, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX, USA.

Curr Cancer Drug Targets ; 22(4): 312-327, 2022.

Article de En | MEDLINE | ID: mdl-34951367

Sujet(s)
Mots clés

MET receptor tyrosine kinase; antibody-drug conjugate; drug delivery; duocarmycin; in vitro cytotoxicity; mouse monoclonal antibody; therapeutic efficacy; tumor xenograft model

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Immunoconjugués / Tumeurs Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Curr Cancer Drug Targets Sujet du journal: ANTINEOPLASICOS / NEOPLASIAS Année: 2022 Type de document: Article Pays d'affiliation: Chine Pays de publication: Pays-Bas

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