Normal tissue exposure and second malignancy risk in vertebral-body-sparing craniospinal irradiation.
Med Dosim
; 47(2): 142-145, 2022.
Article
de En
| MEDLINE
| ID: mdl-34996678
ABSTRACT
The purpose of this study was to compare dose to anterior organs at risk (OARs) and quantify the risk of developing secondary malignancy (SMN) in pediatric patients treated with vertebral-body-sparing (VBS) vs vertebral body (VB) pencil beam scanning proton craniospinal irradiation (CSI). Comparative plans of VBS and VB CSI were created for 10 previously treated patients. Dose-volume histograms were used to evaluate dose to OARs. Absolute excess risk of SMN was calculated according to the organ-specific, radiation-induced cancer incidence based on the organ equivalent dose. OAR dosimetric parameters and absolute excess risk of SMN were compared for VBS and VB plans using the Kruskal-Wallis H test (αâ¯=â¯0.05). VBS CSI leads to significantly lower radiation dose to the heart, esophagus, kidney, liver and bowel. Excluding the vertebral body also significantly decreases the absolute excess risk of SMN for liver, esophagus and bowel. For these reasons, implementation of VBS pencil beam scanning proton CSI should be considered.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Seconde tumeur primitive
/
Irradiation craniospinale
/
Protonthérapie
Type d'étude:
Etiology_studies
/
Risk_factors_studies
Limites:
Child
/
Humans
Langue:
En
Journal:
Med Dosim
Sujet du journal:
RADIOTERAPIA
Année:
2022
Type de document:
Article