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Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits.
Liu, Yang; Dzidotor, Godwin; Le, Thinh T; Vinikoor, Tra; Morgan, Kristin; Curry, Eli J; Das, Ritopa; McClinton, Aneesah; Eisenberg, Ellen; Apuzzo, Lorraine N; Tran, Khanh T M; Prasad, Pooja; Flanagan, Tyler J; Lee, Seok-Woo; Kan, Ho-Man; Chorsi, Meysam T; Lo, Kevin W H; Laurencin, Cato T; Nguyen, Thanh D.
Affiliation
  • Liu Y; Department of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.
  • Dzidotor G; Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USA.
  • Le TT; Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT 06269, USA.
  • Vinikoor T; Department of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.
  • Morgan K; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
  • Curry EJ; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
  • Das R; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • McClinton A; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
  • Eisenberg E; Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USA.
  • Apuzzo LN; Division of Oral and Maxillofacial Diagnostic Sciences, School of Dental Medicine, University of Connecticut, Farmington, CT 06030, USA.
  • Tran KTM; Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, School of Medicine, University of Connecticut, Farmington, CT 06030, USA.
  • Prasad P; Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA.
  • Flanagan TJ; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
  • Lee SW; Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA.
  • Kan HM; Department of Materials Science and Engineering, University of Connecticut, Storrs, CT 06269, USA.
  • Chorsi MT; Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA.
  • Lo KWH; Department of Materials Science and Engineering, University of Connecticut, Storrs, CT 06269, USA.
  • Laurencin CT; Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA.
  • Nguyen TD; Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USA.
Sci Transl Med ; 14(627): eabi7282, 2022 01 12.
Article de En | MEDLINE | ID: mdl-35020409
ABSTRACT
More than 32.5 million American adults suffer from osteoarthritis, and current treatments including pain medicines and anti-inflammatory drugs only alleviate symptoms but do not cure the disease. Here, we have demonstrated that a biodegradable piezoelectric poly(L-lactic acid) (PLLA) nanofiber scaffold under applied force or joint load could act as a battery-less electrical stimulator to promote chondrogenesis and cartilage regeneration. The PLLA scaffold under applied force or joint load generated a controllable piezoelectric charge, which promoted extracellular protein adsorption, facilitated cell migration or recruitment, induced endogenous TGF-ß via calcium signaling pathway, and improved chondrogenesis and cartilage regeneration both in vitro and in vivo. Rabbits with critical-sized osteochondral defects receiving the piezoelectric scaffold and exercise treatment experienced hyaline-cartilage regeneration and completely healed cartilage with abundant chondrocytes and type II collagen after 1 to 2 months of exercise (2 to 3 months after surgery including 1 month of recovery before exercise), whereas rabbits treated with nonpiezoelectric scaffold and exercise treatment had unfilled defect and limited healing. The approach of combining biodegradable piezoelectric tissue scaffolds with controlled mechanical activation (via physical exercise) may therefore be useful for the treatment of osteoarthritis and is potentially applicable to regenerating other injured tissues.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Arthrose / Cartilage articulaire Limites: Animals Langue: En Journal: Sci Transl Med Sujet du journal: CIENCIA / MEDICINA Année: 2022 Type de document: Article Pays d'affiliation: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Arthrose / Cartilage articulaire Limites: Animals Langue: En Journal: Sci Transl Med Sujet du journal: CIENCIA / MEDICINA Année: 2022 Type de document: Article Pays d'affiliation: États-Unis d'Amérique