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Non-motor effects of subthalamic nucleus stimulation in Parkinson patients.
Sammartino, Francesco; Marsh, Rachel; Rezai, Ali; Krishna, Vibhor.
Affiliation
  • Sammartino F; Center for Neuromodulation, 480 Medical Center Dr., S1019, Columbus, OH, 43210, USA.
  • Marsh R; Center for Neuromodulation, 480 Medical Center Dr., S1019, Columbus, OH, 43210, USA.
  • Rezai A; WVU Rockefeller Neuroscience Institute, 8 Medical Center Drive, Morgantown, WV, 26506, USA.
  • Krishna V; Center for Neuromodulation, 480 Medical Center Dr., S1019, Columbus, OH, 43210, USA. vibhor.krishna@osumc.edu.
Brain Imaging Behav ; 16(1): 161-168, 2022 Feb.
Article de En | MEDLINE | ID: mdl-35029801
ABSTRACT
The current white matter connectivity analyses of the subthalamic region have focused on the motor effects of deep brain stimulation. We investigate white matter connectivity associated with the stimulation-induced non-motor acute clinical effects in three domains mood changes, dizziness, and sweating. We performed whole-brain probabilistic tractography seeded from the domain-specific stimulation volumes. The resultant connectivity maps were statistically compared across patients. The cortical voxels associated with each non-motor domain were compared with stimulation-induced motor improvements in a multivariate model. The resulting voxel maps were thresholded for false discovery (FDR q < 0.05) and clustered using a multimodal atlas. We also performed a group-level parcellation of stimulation volumes to identify the local pathways associated with each non-motor domain. The non-motor effects were rarely observed during stimulation titration from 1100 acute clinical effects, mood change was observed in 14, dizziness in 23, and sweating in 20. Distinct cortical clusters were associated with each domain; notably, mood change was associated with voxels in the salience network and dizziness with voxels in the visual association cortex. The subthalamic parcellation yielded a mediolateral gradient, with the motor parcel being lateral and the non-motor parcels medial. We also observed an anteroposterior organization in the medial non-motor clusters with mood changes being anterior, followed posteriorly by dizziness, and sweating. We interpret these findings based on the literature and foresee these to be useful in guiding DBS programming.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladie de Parkinson / Noyau subthalamique / Stimulation cérébrale profonde / Substance blanche Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Brain Imaging Behav Sujet du journal: CEREBRO / CIENCIAS DO COMPORTAMENTO / DIAGNOSTICO POR IMAGEM Année: 2022 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladie de Parkinson / Noyau subthalamique / Stimulation cérébrale profonde / Substance blanche Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Brain Imaging Behav Sujet du journal: CEREBRO / CIENCIAS DO COMPORTAMENTO / DIAGNOSTICO POR IMAGEM Année: 2022 Type de document: Article Pays d'affiliation: États-Unis d'Amérique