NTRK-rearranged spindle cell neoplasm of the lower extremity: radiologic-pathologic correlation.
Skeletal Radiol
; 51(8): 1707-1713, 2022 Aug.
Article
de En
| MEDLINE
| ID: mdl-35031835
ABSTRACT
Neurotrophic tyrosine receptor kinase (NTRK)-rearranged spindle cell neoplasm is a recently characterized soft tissue tumor and has been classified as provisional by the World Health Organization. Detection of the genetic rearrangement is important because these tumors are amenable to targeted tyrosine kinase inhibitor therapy, which can play a key role in patients with unresectable or advanced disease. Although the spectrum of histopathology associated with this entity is broad, one notable feature is the infiltrative growth pattern, which is most reminiscent of lipofibromatosis-like neural tumor. Description of their diverse histologic attributes has aided recognition, but so far little attention has been paid to correlating the gross appearance and imaging features of these lesions. In this report, we describe the clinical, imaging, histopathological, and genetic features of a soft tissue NTRK-rearranged spindle cell neoplasm. Inclusion of this more recently identified entity into the imaging differential of tumors with intratumoral relatively hypovascular nodules and infiltrative margins is important because testing for NTRK rearrangement is not routinely performed.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs des tissus mous
/
Récepteur trkA
Limites:
Humans
Langue:
En
Journal:
Skeletal Radiol
Année:
2022
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique