5-<i>C</i>-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease.

Kato, Atsushi; Nakagome, Izumi; Kanekiyo, Uta; Lu, Tian-Tian; Li, Yi-Xian; Yoshimura, Kosuke; Kishida, Mana; Shinzawa, Kenta; Yoshida, Tomoki; Tanaka, Nobutada; Jia, Yue-Mei; Nash, Robert J; Fleet, George W J; Yu, Chu-Yi

5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease.

Kato, Atsushi; Nakagome, Izumi; Kanekiyo, Uta; Lu, Tian-Tian; Li, Yi-Xian; Yoshimura, Kosuke; Kishida, Mana; Shinzawa, Kenta; Yoshida, Tomoki; Tanaka, Nobutada; Jia, Yue-Mei; Nash, Robert J; Fleet, George W J; Yu, Chu-Yi.

Affiliation

Kato A; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Nakagome I; School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan.
Kanekiyo U; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Lu TT; Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Li YX; University of Chinese Academy of Sciences, Beijing 100049, China.
Yoshimura K; Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Kishida M; University of Chinese Academy of Sciences, Beijing 100049, China.
Shinzawa K; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Yoshida T; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Tanaka N; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Jia YM; School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan.
Nash RJ; School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan.
Fleet GWJ; Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Yu CY; University of Chinese Academy of Sciences, Beijing 100049, China.

J Med Chem ; 65(3): 2329-2341, 2022 02 10.

Article de En | MEDLINE | ID: mdl-35072486

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: 1-Désoxynojirimycine / Antienzymes / Alpha-Glucosidase Limites: Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2022 Type de document: Article Pays d'affiliation: Japon Pays de publication: États-Unis d'Amérique

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