Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of <i>Candidiasis</i>.

Wen, Wuqiang; Cao, Hongxuan; Huang, Yunyuan; Tu, Jie; Wan, Chen; Wan, Jian; Han, Xinya; Chen, Han; Liu, Jiaqi; Rao, Li; Su, Chen; Peng, Chao; Sheng, Chunquan; Ren, Yanliang

Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis.

Wen, Wuqiang; Cao, Hongxuan; Huang, Yunyuan; Tu, Jie; Wan, Chen; Wan, Jian; Han, Xinya; Chen, Han; Liu, Jiaqi; Rao, Li; Su, Chen; Peng, Chao; Sheng, Chunquan; Ren, Yanliang.

Affiliation

Wen W; Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Cao H; Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Huang Y; Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Tu J; School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Wan C; Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Wan J; Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Han X; Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Chen H; Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Liu J; Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Rao L; Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Su C; National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai 201210, China.
Peng C; National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai 201210, China.
Sheng C; School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Ren Y; Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.

J Med Chem ; 65(3): 2656-2674, 2022 02 10.

Article de En | MEDLINE | ID: mdl-35099959

Sujet(s)

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Azoles / Protéines fongiques / Résistance des champignons aux médicaments / Antienzymes / Fructose bisphosphate aldolase / Antifongiques Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2022 Type de document: Article Pays d'affiliation: Chine Pays de publication: États-Unis d'Amérique

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google