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Impact of continuous pharmacist intervention for injectable antimicrobials on the treatment of patients with Escherichia coli bacteremia.
Shinoda, Yasutaka; Ohashi, Kengo; Matsuoka, Tomoko; Arai, Kaori; Hotta, Nao; Asano, Izumi; Yoshimura, Tomoaki.
Affiliation
  • Shinoda Y; Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Japan. Electronic address: shonoda065039@gmail.com.
  • Ohashi K; Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Japan.
  • Matsuoka T; Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Japan.
  • Arai K; Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Japan.
  • Hotta N; Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Japan.
  • Asano I; Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Japan.
  • Yoshimura T; Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Japan.
Am J Infect Control ; 50(10): 1150-1155, 2022 10.
Article de En | MEDLINE | ID: mdl-35121041
ABSTRACT

BACKGROUND:

A prospective audit with intervention and feedback (PAF) by pharmacists is important for the appropriate use of antimicrobials. Clinically, Escherichia coli (E. coli) bacteremia is a common condition, but only few researchers have examined the role of PAF in its appropriate use of antimicrobials.

METHODS:

We started PAF by pharmacists in 2017 for all injectable antibiotics. This study included cases of E. coli bacteremia that resulted in hospitalization over a 4 year period from 2016 to 2019. Patients were grouped by year (Period 0-3), and clinical outcomes were examined.

RESULTS:

The pharmacists had 12 and 54 suggestions in Periods 0 and 3, respectively. The most common suggestion was de-escalation. The median duration of antimicrobial use was 12 (interquartile range 8-15) days in Periods 0-2. The duration of antimicrobial use was significantly reduced to 9 (7-12) days in Period 3. In Period 3, the duration of antimicrobial use was reduced by 29%, while anti-pseudomonal drug use was reduced by 42% compared with that in period 0. The 30 day mortality rates were not significantly different between the groups.

CONCLUSIONS:

PAF by pharmacists promotes the appropriate use of antimicrobials in patients with E. coli bacteremia; it is important to continue the program for several years.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Bactériémie / Infections à Escherichia coli / Anti-infectieux Limites: Humans Langue: En Journal: Am J Infect Control Année: 2022 Type de document: Article

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Bactériémie / Infections à Escherichia coli / Anti-infectieux Limites: Humans Langue: En Journal: Am J Infect Control Année: 2022 Type de document: Article