Sex, estrous cycle, and hormone regulation of CYP2D in the brain alters oxycodone metabolism and analgesia.

Arguelles, Nicole; Richards, Janielle; El-Sherbeni, Ahmed A; Miksys, Sharon; Tyndale, Rachel F

Arguelles, Nicole; Richards, Janielle; El-Sherbeni, Ahmed A; Miksys, Sharon; Tyndale, Rachel F.

Affiliation

Arguelles N; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
Richards J; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
El-Sherbeni AA; Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Miksys S; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Canada.
Tyndale RF; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address: r.tyndal

Biochem Pharmacol ; 198: 114949, 2022 04.

Article de En | MEDLINE | ID: mdl-35143755

Sujet(s)
Mots clés

Analgesia; CYP2D; Estradiol; Estrous cycle; Ovariectomy; Oxycodone

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Oxycodone / Analgésie Limites: Animals Langue: En Journal: Biochem Pharmacol Année: 2022 Type de document: Article Pays d'affiliation: Canada

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