Anti-rheumatic activity of topical nanoemulsion containing bee venom in rats.
Eur J Pharm Biopharm
; 172: 168-176, 2022 Mar.
Article
de En
| MEDLINE
| ID: mdl-35149192
ABSTRACT
PURPOSE:
Bee Venom (BV) has been used to treat rheumatoid arthritis (RA) for many centuries. However, its clinical use is limited by pain and fear of bee stings/injection. Nanoemulsions (NEs) are nanocarriers that are able to help their content(s) penetrate through the skin. They also act as drug reservoirs on the skin to provide an efficient, sustained-release vehicle.METHODS:
In this paper, we present the development of a stable water-in-oil NE to help passing BV through the animal skin when used topically.RESULTS:
Particle size of NE was 12.7 to 29.8 nm for NEs containing 0 to 150 µg/ml BV. Also, its anti-inflammatory effects were evaluated in rat models of type II collagen-induced arthritis. Topical administration of NEs containing 18.75 or 9.37 µg/ml BV were able to significantly (p < 0.05) reduce inflammation in the rat paws compared to the blank and control groups.CONCLUSION:
Our findings demonstrated the efficacy of NEs containing BV to reduce inflammation caused by RA animal model.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Arthrite expérimentale
/
Polyarthrite rhumatoïde
/
Venins d'abeille
/
Morsures et piqûres d'insectes
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Eur J Pharm Biopharm
Sujet du journal:
FARMACIA
/
FARMACOLOGIA
Année:
2022
Type de document:
Article
Pays d'affiliation:
Iran