Arrested in Glass: Actin within Sophisticated Architectures of Biosilica in Sponges.
Adv Sci (Weinh)
; 9(11): e2105059, 2022 04.
Article
de En
| MEDLINE
| ID: mdl-35156333
ABSTRACT
Actin is a fundamental member of an ancient superfamily of structural intracellular proteins and plays a crucial role in cytoskeleton dynamics, ciliogenesis, phagocytosis, and force generation in both prokaryotes and eukaryotes. It is shown that actin has another function in metazoans patterning biosilica deposition, a role that has spanned over 500 million years. Species of glass sponges (Hexactinellida) and demosponges (Demospongiae), representatives of the first metazoans, with a broad diversity of skeletal structures with hierarchical architecture unchanged since the late Precambrian, are studied. By etching their skeletons, organic templates dominated by individual F-actin filaments, including branched fibers and the longest, thickest actin fiber bundles ever reported, are isolated. It is proposed that these actin-rich filaments are not the primary site of biosilicification, but this highly sophisticated and multi-scale form of biomineralization in metazoans is ptterned.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Actines
/
Silice
Langue:
En
Journal:
Adv Sci (Weinh)
Année:
2022
Type de document:
Article
Pays d'affiliation:
Allemagne