Immunological Predictors of Dimethyl Fumarate-Induced Lymphopenia.

Diebold, Martin; Galli, Edoardo; Kopf, Andreas; Sanderson, Nicholas; Callegari, Ilaria; Ingelfinger, Florian; Núñez, Nicolás Gonzalo; Benkert, Pascal; Kappos, Ludwig; Kuhle, Jens; Becher, Burkhard; Claassen, Manfred; Derfuss, Tobias

Diebold, Martin; Galli, Edoardo; Kopf, Andreas; Sanderson, Nicholas; Callegari, Ilaria; Ingelfinger, Florian; Núñez, Nicolás Gonzalo; Benkert, Pascal; Kappos, Ludwig; Kuhle, Jens; Becher, Burkhard; Claassen, Manfred; Derfuss, Tobias.

Affiliation

Diebold M; Multiple Sclerosis Center, Neurologic Clinic and Policlinic, Department of Biomedicine and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Galli E; Institute of Neuropathology, Neurocenter, University Hospital Freiburg, Freiburg, Germany.
Kopf A; Multiple Sclerosis Center, Neurologic Clinic and Policlinic, Department of Biomedicine and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Sanderson N; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Callegari I; Institute of Molecular Systems Biology, Swiss Federal Institute of Technology in Zurich, Zurich, Switzerland.
Ingelfinger F; Swiss Institute of Bioinformatics, Zurich, Switzerland.
Núñez NG; Life Science Graduate School Zurich, PhD Program in Systems Biology, Zurich, Switzerland.
Benkert P; Multiple Sclerosis Center, Neurologic Clinic and Policlinic, Department of Biomedicine and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Kappos L; Multiple Sclerosis Center, Neurologic Clinic and Policlinic, Department of Biomedicine and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Kuhle J; Institute of Neuropathology, Neurocenter, University Hospital Freiburg, Freiburg, Germany.
Becher B; Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
Claassen M; Institute of Neuropathology, Neurocenter, University Hospital Freiburg, Freiburg, Germany.
Derfuss T; Multiple Sclerosis Center, Neurologic Clinic and Policlinic, Department of Biomedicine and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel, Basel, Switzerland.

Ann Neurol ; 91(5): 676-681, 2022 05.

Article de En | MEDLINE | ID: mdl-35170072

ABSTRACT

ABSTRACT

Treatment with dimethyl fumarate (DMF) leads to lymphopenia and infectious complications in a subset of patients with multiple sclerosis (MS). Here, we aimed to reveal immune markers of DMF-associated lymphopenia. This prospective observational study longitudinally assessed 31 individuals with MS by single-cell mass cytometry before and after 12 and 48 weeks of DMF therapy. Employing a neural network-based representation learning approach, we identified a CCR4-expressing T helper cell population negatively associated with relevant lymphopenia. CCR4-expressing T helper cells represent a candidate prognostic biomarker for the development of relevant lymphopenia in patients undergoing DMF treatment. ANN NEUROL 2022;91676-681.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Sclérose en plaques récurrente-rémittente / Lymphopénie / Sclérose en plaques Type d'étude: Observational_studies / Prognostic_studies / Risk_factors_studies Limites: Humans Langue: En Journal: Ann Neurol Année: 2022 Type de document: Article Pays d'affiliation: Suisse

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