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Pharmacogenetics research in Brazil: a systematic review.
Torres-Loureiro, Sabrina; Scudeler, Mariana M; Andrade, Poliana Xc; Sampaio-Coelho, Julia; Nobre, Igor H; Céspedes-Garro, Carolina; Tarazona-Santos, Eduardo; Llerena, Adrián; Rodrigues-Soares, Fernanda.
Affiliation
  • Torres-Loureiro S; Departamento de Patologia, Genética e Evolução, Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, 38025-350, Brazil.
  • Scudeler MM; Departamento de Patologia, Genética e Evolução, Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, 38025-350, Brazil.
  • Andrade PX; Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 31270-910, Brazil.
  • Sampaio-Coelho J; Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 31270-910, Brazil.
  • Nobre IH; Residência Médica de Pediatria do Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
  • Céspedes-Garro C; Departamento de Patologia, Genética e Evolução, Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, 38025-350, Brazil.
  • Tarazona-Santos E; Genetics Section, School of Biology, University of Costa Rica, San Pedro, San José 11501, Costa Rica.
  • Llerena A; Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 31270-910, Brazil.
  • Rodrigues-Soares F; RIBEF Ibero-American Network of Pharmacogenetics & Pharmacogenomics, Badajoz, Extremadura, Spain.
Pharmacogenomics ; 23(4): 263-275, 2022 03.
Article de En | MEDLINE | ID: mdl-35187980
ABSTRACT

Aim:

Pharmacogenomics (PGx) is a rising scientific area in many countries, such as Brazil.

Objectives:

To identify biomarkers, therapeutic areas, probe drugs and regions/ethnicities most studied in the country in order to guide future studies. Materials &

methods:

Systematic review of 1060 studies (from 1968 to 2020) comprising 80 genes, six probe drugs and 3,819,233 individuals.

Results:

MTHFR and HLA-A/B were the most studied genes and metoprolol and dextromethorphan the most studied probe drugs. Oncology was the most studied therapeutic area considering PGx biomarkers. The country's regions and ethnic groups were studied unevenly, with south/southeast and White people over-represented in respect to their demographic relevance, in detriment of the center-west/northeast/north and Black/mixed individuals.

Conclusion:

Many of the gaps and possible paths to be covered to reach even PGx data are pointed out by this review.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pharmacogénétique / Antigènes HLA-B Type d'étude: Systematic_reviews Limites: Humans Pays/Région comme sujet: America do sul / Brasil Langue: En Journal: Pharmacogenomics Sujet du journal: FARMACOLOGIA / GENETICA MEDICA Année: 2022 Type de document: Article Pays d'affiliation: Brésil
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pharmacogénétique / Antigènes HLA-B Type d'étude: Systematic_reviews Limites: Humans Pays/Région comme sujet: America do sul / Brasil Langue: En Journal: Pharmacogenomics Sujet du journal: FARMACOLOGIA / GENETICA MEDICA Année: 2022 Type de document: Article Pays d'affiliation: Brésil