Modular polymer platform as a novel approach to head and neck cancer therapy.
Sci Rep
; 12(1): 3592, 2022 03 04.
Article
de En
| MEDLINE
| ID: mdl-35246558
ABSTRACT
Head and neck cancer is the sixth most common cancer in the world, with more than 300,000 deaths attributed to the disease annually. Aggressive surgical resection often with adjuvant chemoradiation is the cornerstone of treatment. However, the necessary chemoradiation treatment can result in collateral damage to adjacent vital structures causing a profound impact on quality of life. Here, we present a novel polymer of poly(lactic-co-glycolic) acid and polyvinyl alcohol that can serve as a versatile multidrug delivery platform as well as for detection on cross-sectional imaging while functioning as a fiduciary marker for postoperative radiotherapy and radiotherapeutic dosing. In a mouse xenograft model, the dual-layered polymer composed of calcium carbonate/thymoquinone was used for both polymer localization and narrow-field infusion of a natural therapeutic compound. A similar approach can be applied in the treatment of head and neck cancer patients, where immunotherapy and traditional chemotherapy can be delivered simultaneously with independent release kinetics.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Polymères
/
Tumeurs de la tête et du cou
Aspects:
Patient_preference
Limites:
Animals
/
Humans
Langue:
En
Journal:
Sci Rep
Année:
2022
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique