Assessment of post-partum haemorrhage risk among women with moderate thrombocytopenia.
Br J Haematol
; 197(4): 482-488, 2022 05.
Article
de En
| MEDLINE
| ID: mdl-35266559
ABSTRACT
It is unknown whether moderate thrombocytopenia represents a risk factor for post-partum haemorrhage (PPH). We assessed PPH risk among women with a platelet count of between 100 and 50 × 109 /l and stratified the risk for O/non-O blood group. We included consecutive women undergoing vaginal delivery or caesarean section with moderate thrombocytopenia. Women with >150 × 109 /l platelets at delivery were selected as controls and matched for age, type of birth and ethnicity. Odds ratios (ORs) with their 95% confidence intervals (95% CIs) were calculated as risk estimates. A total of 94 thrombocytopenic women and 94 controls were included in the study. The rate of PPH was significantly higher in thrombocytopenic women than in controls (37% vs. 10%, p < 0.001); there was a higher risk of PPH in the thrombocytopenic group when compared to the control group (adjusted OR 4.7, 95% CI 2.1-10.8, p < 0.01) and this association was stronger in blood group O carriers (adjusted OR 11.0, 95% CI 2.4-49.6, p < 0.01). In conclusion, our study shows that a moderate thrombocytopenia is a risk factor for PPH, especially in blood group O carriers.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Thrombopénie
/
Antigènes de groupe sanguin
/
Hémorragie de la délivrance
/
Leucopénie
Type d'étude:
Etiology_studies
/
Risk_factors_studies
Limites:
Female
/
Humans
/
Male
/
Pregnancy
Langue:
En
Journal:
Br J Haematol
Année:
2022
Type de document:
Article
Pays d'affiliation:
Italie