Propranolol use in patients with cirrhosis and refractory ascites: A nationwide study.
Saudi J Gastroenterol
; 28(2): 108-114, 2022.
Article
de En
| MEDLINE
| ID: mdl-35295067
ABSTRACT
Background:
The impact of propranolol on patients with cirrhosis and refractory ascites is controversial. We conducted a nationwide longitudinal cohort study to compare the survival between patients with cirrhosis and refractory ascites, with and without using propranolol.Methods:
Data of patients with cirrhosis and refractory ascites using propranolol, and controls matched by age and gender, were extracted from The National Health Insurance Research Database of Taiwan. The baseline demographic characteristics were compared between groups. Cox regression analysis was used to examine the predictors of mortality.Results:
In this study, 1788 patients were enrolled in each group; 1304 patients (72.9%) in the propranolol group and 1445 patients (80.8%) in the control group died (P < 0.001). The mean survival was 34.3 ± 31.2 months in the propranolol group and 20.8 ± 26.6 months in the control group (P < 0.001). Propranolol (hazard ratio [HR] 0.60, 95% confidence interval [CI] 0.55-0.64, P < 0.001), statins (HR 0.43, 95% CI 0.34-0.56, P < 0.001), age (HR 1.02, 95% CI 1.01-1.02, P < 0.001), and diabetes mellitus (HR 1.14, 95% CI 1.05-1.24, P = 0.002) were the independent predictors for mortality.Conclusions:
Use of propanolol was associated with reduced mortality, compared with controls, in this nationwide cohort of patients with cirrhosis and refractory ascites.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Propranolol
/
Ascites
Type d'étude:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Humans
Langue:
En
Journal:
Saudi J Gastroenterol
Sujet du journal:
GASTROENTEROLOGIA
Année:
2022
Type de document:
Article
Pays d'affiliation:
Taïwan