Neutrophil count is a useful marker to predict the severity of preeclampsia.
Clin Exp Hypertens
; 44(4): 334-340, 2022 May 19.
Article
de En
| MEDLINE
| ID: mdl-35343343
ABSTRACT
BACKGROUND:
At present, pre-eclampsia is a growing concern and still a diagnostic challenge for obstetricians.AIMS:
This study aimed to evaluate whether the relationship of second trimester of pregnancy neutrophil count differed among pregnancies with mild preeclampsia, severe preeclampsia, and healthy status and explore whether or not neutrophil count in the second trimester of pregnancy would be useful as new predictors of subsequent preeclampsia. PATIENTS ANDMETHODS:
This study involved 933 pregnancies from 1 January 2018 to 30 January 2021, comprising 396 healthy pregnancies, 222 pregnancies with mild preeclampsia, and 315 pregnancies with severe preeclampsia. The relationship between preeclampsia and neutrophil count was analyzed by multiple logistic regression. In addition, maternal placental tissues of three groups were immunohistochemically stained for myeloperoxidase (MPO).RESULTS:
Neutrophil count was significantly higher in pregnancies with preeclampsia (including pregnancies with mild and severe preeclampsia) than that in healthy pregnancies. The neutrophil count level was prominently higher in patients with severe preeclampsia compared with those with mild preeclampsia (p < .001). The neutrophil count level was significantly positively associated with preeclampsia after adjusting for gestational week at time of blood sampling, BMI, and age (ß1.23; 95%CI1.09-1.36; p < .0001). In addition, MPO expressions of placental tissues in preeclamptic groups were significantly increased than these in healthy pregnant controls (p < .05).CONCLUSIONS:
Increased neutrophil count in the second trimester of pregnancy was significantly positively associated with preeclampsia. Hence, neutrophil count plays a role in predicting the severity of preeclampsia. At the same time, it may be an independent predictor of subsequent preeclampsia.Abbreviations BMI body mass index; MPO myeloperoxidase.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pré-éclampsie
Type d'étude:
Prognostic_studies
/
Risk_factors_studies
Limites:
Female
/
Humans
/
Pregnancy
Langue:
En
Journal:
Clin Exp Hypertens
Année:
2022
Type de document:
Article
Pays d'affiliation:
Chine