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Development and Validation of a Screening Questionnaire of COPD from a Large Epidemiological Study in China.
Wang, Dingyi; Fan, Guohui; Wu, Sinan; Yang, Ting; Xu, Jianying; Yang, Lan; Zhao, Jianping; Zhang, Xiangyan; Bai, Chunxue; Kang, Jian; Ran, Pixin; Shen, Huahao; Wen, Fuqiang; Huang, Kewu; Chen, Yahong; Sun, Tieying; Shan, Guangliang; Lin, Yingxiang; Xu, Guodong; Wang, Ruiying; Shi, Zhihong; Xu, Yongjian; Ye, Xianwei; Song, Yuanlin; Wang, Qiuyue; Zhou, Yumin; Li, Wen; Ding, Liren; Wan, Chun; Yao, Wanzhen; Guo, Yanfei; Xiao, Fei; Lu, Yong; Peng, Xiaoxia; Zhang, Biao; Xiao, Dan; Wang, Zuomin; Bu, Xiaoning; Zhang, Hong; Zhang, Xiaolei; An, Li; Zhang, Shu; Zhu, Jianguo; Cao, Zhixin; Zhan, Qingyuan; Yang, Yuanhua; Liang, Lirong; Dai, Huaping; Cao, Bin; He, Jiang.
Affiliation
  • Wang D; China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Clinical Medical Sciences, Beijing, China; Chinese Academy of Medical Sciences, Institute of Respiratory Medicine, Beijing, China.
  • Fan G; China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Clinical Medical Sciences, Beijing, China; Chinese Academy of Medical Sciences, Institute of Respiratory Medicine, Beijing, China.
  • Wu S; Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Center for Respiratory Medicine, Beijing, China; Chinese Academy of Medical Sciences, Institute of Respiratory Medicine, Beijing, China.
  • Yang T; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Center for Respiratory Medicine, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • Xu J; Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital, Taiyuan, China.
  • Yang L; Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Zhao J; Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang X; Department of Pulmonary and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
  • Bai C; Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Kang J; Department of Pulmonary and Critical Care Medicine, First Hospital of China Medical University, Shenyang, China.
  • Ran P; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
  • Shen H; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
  • Wen F; State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China.
  • Huang K; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, China.
  • Chen Y; Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
  • Sun T; Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China; National Center of Gerontology, Beijing Hospital, Beijing, China.
  • Shan G; Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Beijing, China.
  • Lin Y; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, China.
  • Xu G; China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Clinical Medical Sciences, Beijing, China; Chinese Academy of Medical Sciences, Institute of Respiratory Medicine, Beijing, China.
  • Wang R; Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital, Taiyuan, China.
  • Shi Z; Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Xu Y; Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Ye X; Department of Pulmonary and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
  • Song Y; Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Wang Q; Department of Pulmonary and Critical Care Medicine, First Hospital of China Medical University, Shenyang, China.
  • Zhou Y; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
  • Li W; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
  • Ding L; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
  • Wan C; State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China.
  • Yao W; Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
  • Guo Y; Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China; National Center of Gerontology, Beijing Hospital, Beijing, China.
  • Xiao F; National Center of Gerontology, Beijing Hospital, Beijing, China.
  • Lu Y; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, China.
  • Peng X; Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
  • Zhang B; Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Beijing, China.
  • Xiao D; Tobacco Medicine and Tobacco Cessation Center, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China; National Clinical Research Center for Respiratory Diseases, Beijing, China; WHO Coll
  • Wang Z; Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
  • Bu X; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, China.
  • Zhang H; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, China.
  • Zhang X; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Center for Respiratory Medicine, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • An L; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, China.
  • Zhang S; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, China.
  • Zhu J; National Center of Gerontology, Beijing Hospital, Beijing, China.
  • Cao Z; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, China.
  • Zhan Q; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Center for Respiratory Medicine, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • Yang Y; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, China.
  • Liang L; Department of Epidemiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China; Beijing Institute of Respiratory Medicine, Beijing, China.
  • Dai H; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Center for Respiratory Medicine, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • Cao B; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Center for Respiratory Medicine, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
COPD ; 19(1): 118-124, 2022.
Article de En | MEDLINE | ID: mdl-35385369
ABSTRACT

OBJECTIVE:

We aimed to establish an easy-to-use screening questionnaire with risk factors and suspected symptoms of COPD for primary health care settings.

METHODS:

Based on a nationwide epidemiological study of pulmonary health among adults in mainland China (China Pulmonary Health, CPH study) between 2012 and 2015, participants ≥40 years who completed the questionnaire and spirometry tests were recruited and randomly divided into development set and validation set by the ratio of 21. Parameters including sex, age, BMI, residence, education, smoking status, smoking pack-years, biomass exposure, parental history of respiratory diseases and daily respiratory symptoms were initially selected for the development of scoring system. Receiver operating characteristic (ROC) curve, area under curve (AUC), positive and negative predictive values were calculated in development set and validation set.

RESULTS:

After random split by 21 ratio, 22443 individuals were assigned to development set and 11221 to validation set. Ten variables were significantly associated with COPD independently in development set after a stepwise selection by multivariable logistic model and used to develop scoring system. The scoring system yielded good discrimination, as measured by AUC of 0.7737, and in the validation set, the AUC was 0.7711. When applying a cutoff point of ≥16, the sensitivity in development set was 0.69 (0.67 - 0.71); specificity 0.72 (0.71 - 0.73), PPV 0.25 (0.24 - 0.26) and NPV 0.94 (0.94 - 0.95).

CONCLUSION:

We developed and validated a comprehensive screening questionnaire, COPD-CPHS, with good discrimination. The score system still needs to be validated by large cohort in the future.Supplemental data for this article is available online at https//doi.org/10.1080/15412555.2022.2042504 .
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Broncho-pneumopathie chronique obstructive Type d'étude: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limites: Adult / Humans Pays/Région comme sujet: Asia Langue: En Journal: COPD Année: 2022 Type de document: Article Pays d'affiliation: Chine
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Broncho-pneumopathie chronique obstructive Type d'étude: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limites: Adult / Humans Pays/Région comme sujet: Asia Langue: En Journal: COPD Année: 2022 Type de document: Article Pays d'affiliation: Chine