Risk factors for carriage of antimicrobial-resistant bacteria in community dwelling-children in the Asia-Pacific region: a systematic review and meta-analysis.
JAC Antimicrob Resist
; 4(2): dlac036, 2022 Apr.
Article
de En
| MEDLINE
| ID: mdl-35449720
ABSTRACT
Background:
Antimicrobial resistance is an increasingly important issue in public health as antibiotics are overused. Resistance to antimicrobial agents can pose significant challenges to infection treatment.Objectives:
To evaluate risk factors associated with carriage of antimicrobial-resistant (AMR) bacteria in children in the Asia-Pacific region to consolidate evidence for future implementation of antibiotic prescribing practice.Methods:
Three electronic databases-PubMed, EMBASE and Cochrane Library-were searched. Observational studies that investigated the risk factors for carriage of MRSA, penicillin-resistant Streptococcus pneumoniae, ESBL-producing Escherichia coli and Klebsiella pneumoniae among the paediatric population in community settings in the Asia-Pacific region were considered eligible. Summary statistics from the identified studies were pooled using meta-analyses.Results:
From the 4145 search results, 25 papers were included in this review. Sixteen papers were included in the meta-analysis based on reported risk factors. Young age of 2-6â months compared with children aged 7-60â months (OR 2.74, 95% CI 1.75-4.29), antibiotic use within the past 3â months (OR 2.65, 95% CI 1.70-4.12), daycare attendance (OR 1.49, 95% CI 1.17-1.91) and hospital admission within the past 3â months (OR 3.43, 95% CI 2.13-5.51) were found to be significant risk factors for AMR bacterial carriage, whilst breastfeeding (OR 0.69, 95% CI 0.60-0.81) and concurrent colonization of S. pneumoniae (OR 0.59, 95% CI 0.38-0.91) are protective factors.Conclusions:
The findings support that there are a number of significant risk factors associated with carriage of AMR bacteria in the Asia-Pacific paediatric population. To combat antimicrobial resistance in the future, these risk factors should be considered, and measures taken to mitigate associated carriage.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Type d'étude:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Langue:
En
Journal:
JAC Antimicrob Resist
Année:
2022
Type de document:
Article
Pays d'affiliation:
Chine