Renoprotective effects of ferric citrate in a mouse model of chronic kidney disease.
Sci Rep
; 12(1): 6695, 2022 04 23.
Article
de En
| MEDLINE
| ID: mdl-35461329
ABSTRACT
In chronic kidney disease, ferric citrate has been shown to be an effective phosphate binder and source of enteral iron; however, the effects of ferric citrate on the kidney have been less well-studied. Here, in Col4α3 knockout mice-a murine model of progressive chronic kidney disease, we evaluated the effects of five weeks of 1% ferric citrate dietary supplementation. As expected, ferric citrate lowered serum phosphate concentrations and increased serum iron levels in the Col4α3 knockout mice. Consistent with decreased enteral phosphate absorption and possibly improved iron status, ferric citrate greatly reduced circulating fibroblast growth factor 23 levels. Interestingly, ferric citrate also lessened systemic inflammation, improved kidney function, reduced albuminuria, and decreased kidney inflammation and fibrosis, suggesting renoprotective effects of ferric citrate in the setting of chronic kidney disease. The factors mediating possible ferric citrate renoprotection, the mechanisms by which they may act, and whether ferric citrate affects chronic kidney disease progression in humans deserves further study.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Composés du fer III
/
Insuffisance rénale chronique
Type d'étude:
Prognostic_studies
Limites:
Animals
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Sci Rep
Année:
2022
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique