Perinatal outcomes of women with gestational breast cancer in Australia and New Zealand: A prospective population-based study.
Birth
; 49(4): 763-773, 2022 12.
Article
de En
| MEDLINE
| ID: mdl-35470904
ABSTRACT
OBJECTIVE:
To determine the epidemiology, clinical management, and outcomes of women with gestational breast cancer (GBC).METHODS:
A population-based prospective cohort study was conducted in Australia and New Zealand between 2013 and 2014 using the Australasian Maternity Outcomes Surveillance System (AMOSS). Women who gave birth with a primary diagnosis of breast cancer during pregnancy were included. Data were collected on demographic and pregnancy factors, GBC diagnosis, obstetric and cancer management, and perinatal outcomes. The main outcome measures were preterm birth, maternal complications, breastfeeding, and death.RESULTS:
Forty women with GBC (incidence 7.5/100 000 women giving birth) gave birth to 40 live-born babies. Thirty-three (82.5%) women had breast symptoms at diagnosis. Of 27 women diagnosed before 30 weeks' gestation, 85% had breast surgery and 67% had systemic therapy during pregnancy. In contrast, all 13 women diagnosed from 30 weeks had their cancer management delayed until postdelivery. There were 17 preterm deliveries; 15 were planned. Postpartum complications included the following hemorrhage (n = 4), laparotomy (n = 1), and thrombocytopenia (n = 1). There was one late maternal death. Eighteen (45.0%) women initiated breastfeeding, including 12 of 23 women who had antenatal breast surgery. There were no perinatal deaths or congenital malformations, but 42.5% of babies were preterm, and 32.5% were admitted for higher-level neonatal care.CONCLUSIONS:
Gestational breast cancer diagnosed before 30 weeks' gestation was associated with surgical and systemic cancer care during pregnancy and planned preterm birth. In contrast, cancer treatment was deferred to postdelivery for women diagnosed from 30 weeks, reflecting the complexity of managing expectant mothers with GBC in multidisciplinary care settings.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Complications tumorales de la grossesse
/
Tumeurs du sein
/
Issue de la grossesse
Type d'étude:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
Limites:
Female
/
Humans
/
Newborn
/
Pregnancy
Pays/Région comme sujet:
Oceania
Langue:
En
Journal:
Birth
Année:
2022
Type de document:
Article
Pays d'affiliation:
Australie