Ataluren binds to multiple protein synthesis apparatus sites and competitively inhibits release factor-dependent termination.

Huang, Shijie; Bhattacharya, Arpan; Ghelfi, Mikel D; Li, Hong; Fritsch, Clark; Chenoweth, David M; Goldman, Yale E; Cooperman, Barry S

Huang, Shijie; Bhattacharya, Arpan; Ghelfi, Mikel D; Li, Hong; Fritsch, Clark; Chenoweth, David M; Goldman, Yale E; Cooperman, Barry S.

Affiliation

Huang S; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Bhattacharya A; GSK, 14200 Shady Grove Rd, Rockville, MD, 20850, USA.
Ghelfi MD; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Li H; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Fritsch C; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Chenoweth DM; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Goldman YE; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Cooperman BS; Department of Chemistry, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Nat Commun ; 13(1): 2413, 2022 05 06.

Article de En | MEDLINE | ID: mdl-35523781

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Ribosomes / Biosynthèse des protéines Type d'étude: Prognostic_studies Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2022 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: Royaume-Uni

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