Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis.
Org Lett
; 24(20): 3636-3641, 2022 05 27.
Article
de En
| MEDLINE
| ID: mdl-35575720
ABSTRACT
We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprecedented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY-BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Photothérapie dynamique
Type d'étude:
Guideline
Langue:
En
Journal:
Org Lett
Sujet du journal:
BIOQUIMICA
Année:
2022
Type de document:
Article
Pays d'affiliation:
Espagne