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Migraine-Associated Common Genetic Variants Confer Greater Risk of Posterior vs. Anterior Circulation Ischemic Stroke☆.
Frid, P; Xu, H; Mitchell, B D; Drake, M; Wasselius, J; Gaynor, B; Ryan, K; Giese, A K; Schirmer, M; Donahue, K L; Irie, R; Bouts, M J R J; McIntosh, E C; Mocking, S J T; Dalca, A V; Giralt-Steinhauer, E; Holmegaard, L; Jood, K; Roquer, J; Cole, J W; McArdle, P F; Broderick, J P; Jimenez-Conde, J; Jern, C; Kissela, B M; Kleindorfer, D O; Lemmens, R; Meschia, J F; Rosand, J; Rundek, T; Sacco, R L; Schmidt, R; Sharma, P; Slowik, A; Thijs, V; Woo, D; Worrall, B B; Kittner, S J; Petersson, J; Golland, P; Wu, O; Rost, N S; Lindgren, A.
Affiliation
  • Frid P; Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden; Section of Neurology, Skåne University Hospital, Malmö, Sweden. Electronic address: petrea.frid@med.lu.se.
  • Xu H; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: hxu@som.umaryland.edu.
  • Mitchell BD; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, MD, USA.
  • Drake M; Department of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden; Department of Radiology, Neuroradiology, Skåne University Hospital, Lund, Sweden.
  • Wasselius J; Department of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden; Department of Radiology, Neuroradiology, Skåne University Hospital, Lund, Sweden.
  • Gaynor B; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Ryan K; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Giese AK; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Schirmer M; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Donahue KL; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Irie R; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Bouts MJRJ; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • McIntosh EC; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Mocking SJT; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Dalca AV; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, USA.
  • Giralt-Steinhauer E; Department of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Spain.
  • Holmegaard L; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Jood K; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Roquer J; Department of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Spain.
  • Cole JW; Department of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, USA.
  • McArdle PF; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Broderick JP; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Jimenez-Conde J; Department of Neurology, Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Spain.
  • Jern C; Department of Laboratory Medicine, Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Kissela BM; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Kleindorfer DO; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Lemmens R; Department of Neurosciences, Experimental Neurology, VIB Center for Brain & Disease Research, Department of Neurology, University Hospitals Leuven, KU Leuven - University of Leuven, Leuven, Belgium.
  • Meschia JF; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
  • Rosand J; Henry and Allison McCance Center for Brain Health Massachusetts General Hospital, Boston, USA.
  • Rundek T; Department of Neurology, Miller School of Medicine, University of Miami, The Evelyn F. McKnight Brain Institute, FL, USA.
  • Sacco RL; Department of Neurology, Miller School of Medicine, University of Miami, The Evelyn F. McKnight Brain Institute, FL, USA.
  • Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Austria.
  • Sharma P; Institute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), Egham, United Kingdom.
  • Slowik A; Department of Neurology, Jagiellonian University Medical College, Krakow, Poland.
  • Thijs V; Stroke Division, Florey Institute of Neuroscience and Mental Health, and Department of Neurology, Austin Health, Heidelberg, Australia.
  • Woo D; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Worrall BB; Departments of Neurology and Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
  • Kittner SJ; Department of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, USA.
  • Petersson J; Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden.
  • Golland P; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, USA.
  • Wu O; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Rost NS; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Lindgren A; Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden; Section of Neurology, Skåne University Hospital, Lund, Sweden.
J Stroke Cerebrovasc Dis ; 31(8): 106546, 2022 Aug.
Article de En | MEDLINE | ID: mdl-35576861
ABSTRACT

OBJECTIVE:

To examine potential genetic relationships between migraine and the two distinct phenotypes posterior circulation ischemic stroke (PCiS) and anterior circulation ischemic stroke (ACiS), we generated migraine polygenic risk scores (PRSs) and compared these between PCiS and ACiS, and separately vs. non-stroke control subjects.

METHODS:

Acute ischemic stroke cases were classified as PCiS or ACiS based on lesion location on diffusion-weighted MRI. Exclusion criteria were lesions in both vascular territories or uncertain territory; supratentorial PCiS with ipsilateral fetal posterior cerebral artery; and cases with atrial fibrillation. We generated migraine PRS for three migraine phenotypes (any migraine; migraine without aura; migraine with aura) using publicly available GWAS data and compared mean PRSs separately for PCiS and ACiS vs. non-stroke control subjects, and between each stroke phenotype.

RESULTS:

Our primary analyses included 464 PCiS and 1079 ACiS patients with genetic European ancestry. Compared to non-stroke control subjects (n=15396), PRSs of any migraine were associated with increased risk of PCiS (p=0.01-0.03) and decreased risk of ACiS (p=0.010-0.039). Migraine without aura PRSs were significantly associated with PCiS (p=0.008-0.028), but not with ACiS. When comparing PCiS vs. ACiS directly, migraine PRSs were higher in PCiS vs. ACiS for any migraine (p=0.001-0.010) and migraine without aura (p=0.032-0.048). Migraine with aura PRS did not show a differential association in our analyses.

CONCLUSIONS:

Our results suggest a stronger genetic overlap between unspecified migraine and migraine without aura with PCiS compared to ACiS. Possible shared mechanisms include dysregulation of cerebral vessel endothelial function.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Migraine avec aura / Migraine sans aura / Accident vasculaire cérébral ischémique Type d'étude: Etiology_studies / Risk_factors_studies Limites: Humans Langue: En Journal: J Stroke Cerebrovasc Dis Sujet du journal: ANGIOLOGIA / CEREBRO Année: 2022 Type de document: Article
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Migraine avec aura / Migraine sans aura / Accident vasculaire cérébral ischémique Type d'étude: Etiology_studies / Risk_factors_studies Limites: Humans Langue: En Journal: J Stroke Cerebrovasc Dis Sujet du journal: ANGIOLOGIA / CEREBRO Année: 2022 Type de document: Article