Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes.
BMC Med Genomics
; 15(1): 124, 2022 06 04.
Article
de En
| MEDLINE
| ID: mdl-35659227
ABSTRACT
BACKGROUND:
Head circumference is associated with intelligence and tracks from childhood into adulthood.METHODS:
We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.RESULTS:
Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.CONCLUSIONS:
The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cognition
/
Étude d'association pangénomique
Type d'étude:
Systematic_reviews
Limites:
Adult
/
Child
/
Humans
Langue:
En
Journal:
BMC Med Genomics
Sujet du journal:
GENETICA MEDICA
Année:
2022
Type de document:
Article
Pays d'affiliation:
Pays-Bas