Prevalence and Management of Laryngomalacia in Patients With Pierre Robin Sequence.
Cleft Palate Craniofac J
; 60(11): 1395-1403, 2023 11.
Article
de En
| MEDLINE
| ID: mdl-35668613
ABSTRACT
OBJECTIVE:
To characterize the prevalence and presentation of laryngomalacia and efficacy of supraglottoplasty (SGP) in a cohort of patients with Pierre Robin Sequence (PRS).DESIGN:
Retrospective cohort study.SETTING:
Tertiary-care children's hospital. PATIENTS,PARTICIPANTS:
Consecutive patients with PRS born between January 2010 and June 2018. MAIN OUTCOMEMEASURES:
Chart review included demographics, comorbid airway obstruction including laryngomalacia, timing of surgical interventions, clinical symptoms, sleep study data, and modified barium swallow study data.126 patients with PRS were included; 54% had an associated syndrome, 64% had an overt cleft palate, and 22% had a submucous cleft palate. 64/126 were noted to have laryngomalacia (51%). Patients with concurrent PRS and laryngomalacia were significantly more likely to have submucous cleft palate (P = .005) and present with aspiration with cough (P = .01) compared to patients with PRS without laryngomalacia. Patients with concurrent laryngomalacia and PRS showed a significant decrease in apnea-hypopnea index (AHI) and obstructive AHI (OAHI) after mandibular distraction, with a median AHI and OAHI improvement of 22.3 (P = .001) and 19.8 (P = .002), respectively. Patients who underwent only SGP did not show significant improvement in these parameters (P = .112 for AHI, P = .064 for OAHI).The prevalence of laryngomalacia in our PRS cohort was 51%. Patients with PRS and laryngomalacia are more likely to present with overt aspiration compared to patients with PRS without laryngomalacia. These data support that laryngomalacia does not appear to be a contraindication to pursuing MDO.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Syndrome de Pierre Robin
/
Fente palatine
/
Ostéogenèse par distraction
/
Obstruction des voies aériennes
/
Laryngomalacie
Type d'étude:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limites:
Child
/
Humans
/
Infant
Langue:
En
Journal:
Cleft Palate Craniofac J
Sujet du journal:
ODONTOLOGIA
Année:
2023
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique