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Diagnostic challenge of Strongyloides stercoralis hyperinfection syndrome: a case report.
Sterbenc, Anja; Soba, Barbara; Glinsek Biskup, Urska; Fister, Misa; Mikuz, Ursa; Noc, Marko; Luzar, Bostjan.
Affiliation
  • Sterbenc A; Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Soba B; Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Glinsek Biskup U; Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Fister M; Ljubljana University Medical Center, Ljubljana, Slovenia.
  • Mikuz U; Ljubljana University Medical Center, Ljubljana, Slovenia.
  • Noc M; Ljubljana University Medical Center, Ljubljana, Slovenia.
  • Luzar B; Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Article de En | MEDLINE | ID: mdl-35751537
Strongyloides stercoralis causes chronic, mostly asymptomatic infections but hyperinfection syndrome may occur in immunosuppressed patients, especially in those receiving corticosteroids. We report a case of S. stercoralis hyperinfection syndrome in a solid organ transplant recipient that occurred approximately 2.5 months after heart transplantation. The patient presented to the intensive care unit with acute respiratory distress, bacteremia, and petechial rash on abdomen and toe. Microbiology testing of respiratory samples excluded infection with Pneumocystis jirovecii, respiratory viruses, pathogenic bacteria and fungi. No eosinophilia was found. Histopathological examination of the skin biopsy of the petechial rash provided the first indication of the diagnosis, revealing the presence of isolated filariform S. stercoralis larvae in the dermis. Subsequent microbiology testing confirmed the diagnosis. This case highlights the role of histopathological examination of a skin rash in diagnosing patients with atypical clinical presentation of Strongyloides hyperinfection syndrome.
Sujet(s)
Recherche sur Google
Collection: 01-internacional Base de données: MEDLINE Sujet principal: Strongyloïdose / Strongyloides stercoralis / Éosinophilie / Exanthème Type d'étude: Diagnostic_studies / Etiology_studies Limites: Animals / Humans Langue: En Journal: Acta Dermatovenerol Alp Pannonica Adriat Sujet du journal: DERMATOLOGIA / DOENCAS SEXUALMENTE TRANSMISSIVEIS Année: 2022 Type de document: Article Pays d'affiliation: Slovénie Pays de publication: Slovénie
Recherche sur Google
Collection: 01-internacional Base de données: MEDLINE Sujet principal: Strongyloïdose / Strongyloides stercoralis / Éosinophilie / Exanthème Type d'étude: Diagnostic_studies / Etiology_studies Limites: Animals / Humans Langue: En Journal: Acta Dermatovenerol Alp Pannonica Adriat Sujet du journal: DERMATOLOGIA / DOENCAS SEXUALMENTE TRANSMISSIVEIS Année: 2022 Type de document: Article Pays d'affiliation: Slovénie Pays de publication: Slovénie