IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes.
Iran J Immunol
; 19(2): 193-200, 2022 06.
Article
de En
| MEDLINE
| ID: mdl-35767893
ABSTRACT
BACKGROUND:
Obesity and diabetes are related to chronic low-grade inflammation. As a pro-inflammatory cytokine, IL-18 stimulates various cell types and has pleiotropic functions.OBJECTIVE:
To assess the levels of IL-18 in subjects from the entire spectrum of glycemic disorders.METHODS:
This study included 387 Caucasians divided into four groups healthy controls, obese subjects without carbohydrate issues, prediabetic patients, and recently discovered type 2 diabetics.RESULTS:
Subject with body mass index ≥30kg/m2 and glycemic disorders showed significantly high levels of IL-18 (249.77 ± 89.96 pg/ml; 259.01 ± 95.70 pg/ml; and 340.98 ± 127.65 pg/ml) compared with that of the control group (219.47 ± 110.53 pg/ml, p < 0.05). IL-18 also had significant positive associations with some anthropometric parameters, liver enzymes, fasting, post-load glucose, insulin, uric acid, and triglycerides while negative with HDL. The circulating IL-18 levels for differentiating subjects with carbohydrate disturbances and those with metabolic syndrome were determined by ROC analysis. The AUC for the disturbances of the carbohydrate metabolism was 0.597 (p = 0.001; 95% CI = 0.539 - 0.654) and for MS AUC was 0.581 (p = 0.021; 95 % CI = 0.516 - 0.647).CONCLUSION:
Our data indicate that as the levels of IL-18 are increased the carbohydrate tolerance is deteriorated. However, the significance of IL-18 in the progression of diabetes mellitus and subsequent consequences requires further exploration.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
État prédiabétique
/
Interleukine-18
/
Diabète de type 2
/
Obésité
Type d'étude:
Diagnostic_studies
Limites:
Humans
Langue:
En
Journal:
Iran J Immunol
Année:
2022
Type de document:
Article
Pays d'affiliation:
Bulgarie