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IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes.
Nedeva, Iveta; Gateva, Antoaneta; Assyov, Yavor; Karamfilova, Vera; Hristova, Julieta; Yamanishi, Kyosuke; Kamenov, Zdravko; Okamura, Haruki.
Affiliation
  • Nedeva I; Clinic of Endocrinology, University Hospital "Alexandrovska", Department of internal medicine, Medical University-Sofia, Bulgaria.
Iran J Immunol ; 19(2): 193-200, 2022 06.
Article de En | MEDLINE | ID: mdl-35767893
ABSTRACT

BACKGROUND:

Obesity and diabetes are related to chronic low-grade inflammation. As a pro-inflammatory cytokine, IL-18 stimulates various cell types and has pleiotropic functions.

OBJECTIVE:

To assess the levels of IL-18 in subjects from the entire spectrum of glycemic disorders.

METHODS:

This study included 387 Caucasians divided into four groups healthy controls, obese subjects without carbohydrate issues, prediabetic patients, and recently discovered type 2 diabetics.

RESULTS:

Subject with body mass index ≥30kg/m2 and glycemic disorders showed significantly high levels of IL-18 (249.77 ± 89.96 pg/ml; 259.01 ± 95.70 pg/ml; and 340.98 ± 127.65 pg/ml) compared with that of the control group (219.47 ± 110.53 pg/ml, p < 0.05). IL-18 also had significant positive associations with some anthropometric parameters, liver enzymes, fasting, post-load glucose, insulin, uric acid, and triglycerides while negative with HDL. The circulating IL-18 levels for differentiating subjects with carbohydrate disturbances and those with metabolic syndrome were determined by ROC analysis. The AUC for the disturbances of the carbohydrate metabolism was 0.597 (p = 0.001; 95% CI = 0.539 - 0.654) and for MS AUC was 0.581 (p = 0.021; 95 % CI = 0.516 - 0.647).

CONCLUSION:

Our data indicate that as the levels of IL-18 are increased the carbohydrate tolerance is deteriorated. However, the significance of IL-18 in the progression of diabetes mellitus and subsequent consequences requires further exploration.
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Mots clés

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: État prédiabétique / Interleukine-18 / Diabète de type 2 / Obésité Type d'étude: Diagnostic_studies Limites: Humans Langue: En Journal: Iran J Immunol Année: 2022 Type de document: Article Pays d'affiliation: Bulgarie

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: État prédiabétique / Interleukine-18 / Diabète de type 2 / Obésité Type d'étude: Diagnostic_studies Limites: Humans Langue: En Journal: Iran J Immunol Année: 2022 Type de document: Article Pays d'affiliation: Bulgarie