Carrier-free nanoprodrug for p53-mutated tumor therapy via concurrent delivery of zinc-manganese dual ions and ROS.

Wang, Jinping; Qu, Chang; Shao, Xinyue; Song, Guoqiang; Sun, Jingyu; Shi, Donghong; Jia, Ran; An, Hailong; Wang, Hongjun

Wang, Jinping; Qu, Chang; Shao, Xinyue; Song, Guoqiang; Sun, Jingyu; Shi, Donghong; Jia, Ran; An, Hailong; Wang, Hongjun.

Affiliation

Wang J; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, 300401, Tianjin, PR China.
Qu C; Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ, 07030, United States.
Shao X; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, 300401, Tianjin, PR China.
Song G; State Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering, Hebei University of Technology, Tianjin, 300130, PR China.
Sun J; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, 300401, Tianjin, PR China.
Shi D; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, 300401, Tianjin, PR China.
Jia R; Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, 07030, United States.
An H; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, 300401, Tianjin, PR China.
Wang H; State Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering, Hebei University of Technology, Tianjin, 300130, PR China.

Bioact Mater ; 20: 404-417, 2023 Feb.

Article de En | MEDLINE | ID: mdl-35784636

Mots clés

Carrier-free nanoprodrug; Mn-ZnO2 nanoparticle; Reactive oxygen species; Wild-type p53 protein; p53-mutated tumor therapy

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: Bioact Mater Année: 2023 Type de document: Article