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A ratiometric fluorescence probe for selective and sensitive detection of leucine aminopeptidase in lysosome.
Yuan, Di; Xu, Ziwei; Zhang, Bingling; Yin, Xiong; Ye, Jiqing; Zhou, Xiaole; Wang, Leyu.
Affiliation
  • Yuan D; State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, P. R. China. lywang@mail.buct.edu.cn.
  • Xu Z; State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, P. R. China. lywang@mail.buct.edu.cn.
  • Zhang B; State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, P. R. China. lywang@mail.buct.edu.cn.
  • Yin X; State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, P. R. China. lywang@mail.buct.edu.cn.
  • Ye J; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China.
  • Zhou X; State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, P. R. China. lywang@mail.buct.edu.cn.
  • Wang L; State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, P. R. China. lywang@mail.buct.edu.cn.
Chem Commun (Camb) ; 58(60): 8364-8367, 2022 Jul 26.
Article de En | MEDLINE | ID: mdl-35792051
ABSTRACT
We designed a novel ratiometric fluorescent probe P1-Leu with a donor-acceptor-donor fluorophore for the detection of leucine aminopeptidase in lysosomes. P1-Leu exhibits a lower detection limit than the ratiometric donor-π-acceptor probe, due to the low ratiometric background. Besides, P1-Leu has good lysosome-targeting ability and realizes the distinction of LAP levels in different cells.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Colorants fluorescents / Leucyl Aminopeptidase Type d'étude: Diagnostic_studies Langue: En Journal: Chem Commun (Camb) Sujet du journal: QUIMICA Année: 2022 Type de document: Article
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Colorants fluorescents / Leucyl Aminopeptidase Type d'étude: Diagnostic_studies Langue: En Journal: Chem Commun (Camb) Sujet du journal: QUIMICA Année: 2022 Type de document: Article