Regulation of TORC1 by MAPK Signaling Determines Sensitivity and Acquired Resistance to Trametinib in Pediatric BRAFV600E Brain Tumor Models.

Li, Fuyang; Bondra, Kathryn M; Ghilu, Samson; Studebaker, Adam; Liu, Qianqian; Michalek, Joel E; Kogiso, Mari; Li, Xiao-Nan; Kalapurakal, John A; James, C David; Burma, Sandeep; Kurmasheva, Raushan T; Houghton, Peter J

Li, Fuyang; Bondra, Kathryn M; Ghilu, Samson; Studebaker, Adam; Liu, Qianqian; Michalek, Joel E; Kogiso, Mari; Li, Xiao-Nan; Kalapurakal, John A; James, C David; Burma, Sandeep; Kurmasheva, Raushan T; Houghton, Peter J.

Affiliation

Li F; Greehey Children's Cancer Research Institute, UT Health, San Antonio, Texas.
Bondra KM; Greehey Children's Cancer Research Institute, UT Health, San Antonio, Texas.
Ghilu S; Greehey Children's Cancer Research Institute, UT Health, San Antonio, Texas.
Studebaker A; Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, Columbus, Ohio.
Liu Q; Department of Epidemiology and Biostatistics, UT Health, San Antonio, Texas.
Michalek JE; Department of Epidemiology and Biostatistics, UT Health, San Antonio, Texas.
Kogiso M; Department of Pediatrics, Baylor College of Medicine, Texas Children's Cancer Center, Houston, Texas.
Li XN; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Kalapurakal JA; Department of Radiation Oncology and Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
James CD; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Burma S; Department of Neurosurgery, UT Health, San Antonio, Texas.
Kurmasheva RT; Department of Biochemistry and Structural Biology, UT Health, San Antonio, Texas.
Houghton PJ; Greehey Children's Cancer Research Institute, UT Health, San Antonio, Texas.

Clin Cancer Res ; 28(17): 3836-3849, 2022 09 01.

Article de En | MEDLINE | ID: mdl-35797217

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyridones / Pyrimidinones / Tumeurs du cerveau / Complexe-1 cible mécanistique de la rapamycine / Gliome Type d'étude: Diagnostic_studies Limites: Animals / Humans Langue: En Journal: Clin Cancer Res Sujet du journal: NEOPLASIAS Année: 2022 Type de document: Article Pays de publication: États-Unis d'Amérique

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