PIK3CB promotes oesophageal cancer proliferation through the PI3K/AKT/mTOR signalling axis.
Cell Biol Int
; 46(9): 1399-1408, 2022 Sep.
Article
de En
| MEDLINE
| ID: mdl-35842767
ABSTRACT
PIK3CB is abnormally expressed in various carcinomas and affects the proliferation, invasion and drug resistance of cancer cells. However, its role in oesophageal squamous cell carcinoma (ESCC) is still unclear. In this study, PIK3CB was found to be highly expressed in ESCC tissues and cells and positively correlated with the poor prognosis of ESCC. Silencing PIK3CB inhibited the proliferation of ESCC cells, arrested the cell cycle, and promoted apoptosis. Mechanistic studies showed that the tumour-promoting effect of PIK3CB was achieved through PI3K/AKT/mTOR signalling pathway activation. Moreover, the high PIK3CB expression level in ESCC may be closely associated with the hypomethylation status of the gene promoter. In conclusion, PIK3CB promotes ESCC by activating the PI3K/AKT/mTOR signalling axis. PIK3CB may be a potential target in ESCC.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs de l'oesophage
/
Carcinome épidermoïde
Limites:
Humans
Langue:
En
Journal:
Cell Biol Int
Année:
2022
Type de document:
Article
Pays d'affiliation:
Chine