Clinical, Endoscopic, and Radiological Effectiveness of Ustekinumab in Bio-naïve Versus Bio-experienced Patients With Crohn's Disease: Real-world Experience From a Large Canadian Center.

Sedano, Rocio; Guizzetti, Leonardo; McDonald, Cassandra; Beaton, Melanie; Chande, Nilesh; Gregor, Jamie; Sey, Michael; Wilson, Aze; Jairath, Vipul

Sedano, Rocio; Guizzetti, Leonardo; McDonald, Cassandra; Beaton, Melanie; Chande, Nilesh; Gregor, Jamie; Sey, Michael; Wilson, Aze; Jairath, Vipul.

Affiliation

Sedano R; Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada.
Guizzetti L; Alimentiv, Inc., London, Ontario, Canada.
McDonald C; Lawson Health Research Institute, Western University, London, Ontario, Canada.
Beaton M; Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada.
Chande N; Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada.
Gregor J; Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada.
Sey M; Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada.
Wilson A; Lawson Health Research Institute, Western University, London, Ontario, Canada.
Jairath V; Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada.

Inflamm Bowel Dis ; 29(6): 866-874, 2023 06 01.

Article de En | MEDLINE | ID: mdl-35851799

In this large real-world study of patients with Crohn's Disease treated with ustekinumab, we observed high rates of clinical, endoscopic, radiological, and biochemical response and remission rates. Effectiveness was greater in bio-naïve compared with bio-experienced patients.

Sujet(s)
Mots clés

Crohn's disease; real-world; ustekinumab

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladie de Crohn / Ustékinumab Type d'étude: Etiology_studies / Observational_studies / Risk_factors_studies Limites: Adult / Aged / Female / Humans / Male / Middle aged Pays/Région comme sujet: America do norte Langue: En Journal: Inflamm Bowel Dis Sujet du journal: GASTROENTEROLOGIA Année: 2023 Type de document: Article Pays d'affiliation: Canada Pays de publication: Royaume-Uni

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