Penicipurate A, a new polyketide derivative from the endophytic fungus Penicillium purpurogenum.
J Asian Nat Prod Res
; 24(11): 1086-1092, 2022 Nov.
Article
de En
| MEDLINE
| ID: mdl-35852111
ABSTRACT
A new polyketide derivative containing a 3-hydroxydecanoic acid ester moiety, penicipurate A (1), was purified from the solid cultures of the fungus Penicillium purpurogenum, a fungal strain endophytic in the leaves of Edgeworthia chrysantha. The structure of 1 was established by spectroscopic methods, including UV, IR, HRESIMS, 1D, and 2D NMR and 13C NMR chemical shifts calculations coupled with DP4+ analysis, as well as the chemical degradation method. Compound 1 showed moderate inhibitory activity against pancreatic lipase (PL) with an IC50 value of 9.61 ± 1.42 µM.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Penicillium
/
Talaromyces
/
Polycétides
Langue:
En
Journal:
J Asian Nat Prod Res
Sujet du journal:
BOTANICA
/
QUIMICA
Année:
2022
Type de document:
Article
Pays d'affiliation:
Chine