Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos.

Meng, Fanye; Xu, Chenxi; Park, Kwang-Su; Kaniskan, H Ümit; Wang, Gang Greg; Jin, Jian

Meng, Fanye; Xu, Chenxi; Park, Kwang-Su; Kaniskan, H Ümit; Wang, Gang Greg; Jin, Jian.

Affiliation

Meng F; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Xu C; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Park KS; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Kaniskan HÜ; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Wang GG; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Jin J; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

J Med Chem ; 65(15): 10611-10625, 2022 08 11.

Article de En | MEDLINE | ID: mdl-35895319

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Histone-lysine N-methyltransferase / Facteur de transcription Ikaros / Domaines PR-SET Limites: Animals Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2022 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

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