Engineered Cytochrome P450-Catalyzed Oxidative Biaryl Coupling Reaction Provides a Scalable Entry into Arylomycin Antibiotics.

Molinaro, Carmela; Kawasaki, Yukie; Wanyoike, George; Nishioka, Taiki; Yamamoto, Tsuyoshi; Snedecor, Brad; Robinson, Sarah J; Gosselin, Francis

Molinaro, Carmela; Kawasaki, Yukie; Wanyoike, George; Nishioka, Taiki; Yamamoto, Tsuyoshi; Snedecor, Brad; Robinson, Sarah J; Gosselin, Francis.

Affiliation

Molinaro C; Department of Small Molecule Process Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Kawasaki Y; Applied Microbiotechnology Department, MicroBiopharm Japan Co. Ltd., 156 Nakagawara, Kiyosu, Aichi 452-0915, Japan.
Wanyoike G; Production Technology Department, MicroBiopharm Japan Co. Ltd., 1808 Nakaizumi, Iwata, Shizuoka 438-0078, Japan.
Nishioka T; Applied Microbiotechnology Department, MicroBiopharm Japan Co. Ltd., 156 Nakagawara, Kiyosu, Aichi 452-0915, Japan.
Yamamoto T; Applied Microbiotechnology Department, MicroBiopharm Japan Co. Ltd., 156 Nakagawara, Kiyosu, Aichi 452-0915, Japan.
Snedecor B; Department of Cell Culture and Bioprocess Operations, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Robinson SJ; Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Gosselin F; Department of Small Molecule Process Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.

J Am Chem Soc ; 144(32): 14838-14845, 2022 08 17.

Article de En | MEDLINE | ID: mdl-35905381

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Cytochrome P-450 enzyme system / Antibactériens Langue: En Journal: J Am Chem Soc Année: 2022 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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