Beta cell and immune cell interactions in autoimmune type 1 diabetes: How they meet and talk to each other.
Mol Metab
; 64: 101565, 2022 10.
Article
de En
| MEDLINE
| ID: mdl-35944899
ABSTRACT
BACKGROUND:
The highly complex pathogenesis of Type 1 Diabetes is driven by several immune cell types with both effector and regulatory characteristics, which ultimately ends in the destruction of the insulin-producing beta cells. There are multiple layers of interaction between these immune cell populations and the pancreatic islets. SCOPE OF REVIEW In this review article, we aim to discuss important recent insights into the multiple layers of interaction between immune cell populations and the pancreatic islets. Specifically, we discuss the environment where immune and beta cell interactions occur, the key cell types and molecules involved, and the outcomes of these interactions. MAJORCONCLUSIONS:
Most of the molecular mechanisms underlying aberrant immune cell activation and impaired immune tolerance remain insufficiently understood, which hinders the development of efficient prevention and treatment strategies. In order to overcome this knowledge gap, a better understanding of the complex interactions of immune cells and beta cells, including both the underlying protective and pathogenic mechanisms is urgently required.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Ilots pancréatiques
/
Diabète de type 1
/
Cellules à insuline
Limites:
Humans
Langue:
En
Journal:
Mol Metab
Année:
2022
Type de document:
Article
Pays d'affiliation:
Allemagne