Viscosity increase/gelation of therapeutic IgG monoclonal antibodies induced by Zn<sup>2+</sup>: One possible root cause of clogging of staked-in-needle prefilled syringes.

Fukuda, Masakazu; Yamazaki, Tadao; Ueno, Seiji; Koga, Akiko; Yamanaka, Yuji

Viscosity increase/gelation of therapeutic IgG monoclonal antibodies induced by Zn²⁺: One possible root cause of clogging of staked-in-needle prefilled syringes.

Fukuda, Masakazu; Yamazaki, Tadao; Ueno, Seiji; Koga, Akiko; Yamanaka, Yuji.

Affiliation

Fukuda M; Production Engineering Department, Chugai Pharmaceutical Co. Ltd., 5-5-1 Ukima, Kita-ku, Tokyo 115-8543, Japan. Electronic address: fukuda.masakazu76@chugai-pharm.co.jp.
Yamazaki T; Production Engineering Department, Chugai Pharmaceutical Co. Ltd., 5-5-1 Ukima, Kita-ku, Tokyo 115-8543, Japan.
Ueno S; Production Engineering Department, Chugai Pharmaceutical Co. Ltd., 5-5-1 Ukima, Kita-ku, Tokyo 115-8543, Japan.
Koga A; Production Engineering Department, Chugai Pharmaceutical Co. Ltd., 5-5-1 Ukima, Kita-ku, Tokyo 115-8543, Japan.
Yamanaka Y; CMC Development Department, Chugai Pharmaceutical Co., Ltd., 5-5-1 Ukima, Kita-ku, Tokyo 115-8543, Japan.

Eur J Pharm Biopharm ; 178: 179-186, 2022 Sep.

Article de En | MEDLINE | ID: mdl-36029938

Sujet(s)
Mots clés

Clogging; Gelation; High concentration; Monoclonal antibody; Viscosity; Zn(2+)

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Seringues / Anticorps monoclonaux Type d'étude: Prognostic_studies Langue: En Journal: Eur J Pharm Biopharm Sujet du journal: FARMACIA / FARMACOLOGIA Année: 2022 Type de document: Article Pays de publication: Pays-Bas

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