A novel IgG Fc by computer-aided design enhances heavy-chain heterodimerization in bi- or trispecific antibodies.

Wang, Bo; Lin, Jun; Hoag, Matthew R; Wright, Meredith; Ma, Mingjun; Cai, Wenyan; Gallolu Kankanamalage, Sachith; Liu, Yue

Wang, Bo; Lin, Jun; Hoag, Matthew R; Wright, Meredith; Ma, Mingjun; Cai, Wenyan; Gallolu Kankanamalage, Sachith; Liu, Yue.

Affiliation

Wang B; Ab Studio, Inc., Hayward, CA 94545, USA.
Lin J; Genor Biopharma Co. Ltd., Shanghai 201203, P.R.C.
Hoag MR; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai 201203, P.R.C.
Wright M; Ab Studio, Inc., Hayward, CA 94545, USA.
Ma M; Ab Studio, Inc., Hayward, CA 94545, USA.
Cai W; Genor Biopharma Co. Ltd., Shanghai 201203, P.R.C.
Gallolu Kankanamalage S; Ab Studio, Inc., Hayward, CA 94545, USA.
Liu Y; Ab Studio, Inc., Hayward, CA 94545, USA.

Antib Ther ; 5(3): 216-225, 2022 Jul.

Article de En | MEDLINE | ID: mdl-36042698

Mots clés

Fc engineering; bispecific antibodies; computer-aided antibody design; heavy chain heterodimerization; knob-into-hole; multi-specific antibodies; trispecific antibodies

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: Antib Ther Année: 2022 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google