Muscle size, strength, and physical function in response to augmented calorie delivery: A TARGET sub-study.
J Crit Care
; 72: 154140, 2022 12.
Article
de En
| MEDLINE
| ID: mdl-36058058
ABSTRACT
PURPOSE:
Augmented calories may attenuate muscle loss experienced in critical illness. This exploratory sub-study assessed the effect of augmented calorie delivery on muscle mass, strength, and function. MATERIALS ANDMETHODS:
Patients in The Augmented versus Routine approach to Giving Energy Trial (TARGET) randomised to 1.5 kcal/ml or 1.0 kcal/ml enteral formulae at a single-centre were included. Ultrasound-derived muscle layer thickness (MLT) at quadriceps, forearm and mid-upper arm, and handgrip strength, were measured weekly from baseline to hospital discharge, and 3- and 6-months. Physical function was assessed at 3- and 6-months using the 'get up and go' and 6-min walk tests. Data are mean ± SD.RESULTS:
Eighty patients were recruited (1.5 kcal n = 38, 58 ± 14y, 60%M, APACHE II 20 ± 7; 1.0 kcal n = 42, 54 ± 18y, 66%M, APACHE II 22 ± 10). The 1.5 kcal/ml group received more calories with no difference in quadriceps MLT at any timepoint including ICU discharge (primary outcome) (2.90 ± 1.27 vs 2.39 ± 1.06 cm; P = 0.141). Relationships were similar for all MLT measures, handgrip strength, and 6-min walk test. Patients in the 1.5 kcal/ml group had improved 'get up and go' test at 3-months (6.66 ± 1.33 vs. 9.11 ± 2.94 s; P = 0.014).CONCLUSION:
Augmented calorie delivery may not attenuate muscle loss or recovery of strength or function 6-months post-ICU, but this requires exploration in a larger trial.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Ration calorique
/
Force de la main
Type d'étude:
Clinical_trials
Limites:
Humans
Langue:
En
Journal:
J Crit Care
Sujet du journal:
TERAPIA INTENSIVA
Année:
2022
Type de document:
Article