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Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial.
Shoamanesh, Ashkan; Mundl, Hardi; Smith, Eric E; Masjuan, Jaime; Milanov, Ivan; Hirano, Teruyuki; Agafina, Alina; Campbell, Bruce; Caso, Valeria; Mas, Jean-Louis; Dong, Qiang; Turcani, Peter; Christensen, Hanne; Ferro, Jose M; Veltkamp, Roland; Mikulik, Robert; De Marchis, Gian Marco; Robinson, Thompson; Lemmens, Robin; Stepien, Adam; Greisenegger, Stefan; Roine, Risto; Csiba, Laszlo; Khatri, Pooja; Coutinho, Jonathan; Lindgren, Arne G; Demchuk, Andrew M; Colorado, Pablo; Kirsch, Bodo; Neumann, Christoph; Heenan, Laura; Xu, Lizhen; Connolly, Stuart J; Hart, Robert G.
Affiliation
  • Shoamanesh A; Division of Neurology, McMaster University, Population Health Research Institute, Hamilton, ON, Canada. Electronic address: ashkan.shoamanesh@phri.ca.
  • Mundl H; TA Thrombosis and Vascular Medicine, Bayer AG, Wuppertal, Germany.
  • Smith EE; Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Radiology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Masjuan J; Neurology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain; Departamento de Medicina, Facultad de Medicina, Universidad de Alcalá, IRYCIS, RICORS-ICTUS, Madrid, Spain.
  • Milanov I; Medical University, University Hospital for Neurology and Psychiatry "St Naum", Sofia, Bulgaria.
  • Hirano T; Department of Stroke and Cerebrovascular Medicine, School of Medicine, Kyorin University, Tokyo, Japan.
  • Agafina A; Clinical Research Department, City Hospital #40, Saint Petersburg, Russia.
  • Campbell B; Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
  • Caso V; Stroke Unit, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy.
  • Mas JL; Department of Neurology, GHU Paris, Hôpital Sainte-Anne, Université Paris-Cité, Inserm U1266, Paris, France.
  • Dong Q; Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
  • Turcani P; 1st Department of Neurology, Medical Faculty, Comenius University, Bratislava, Slovakia.
  • Christensen H; Department of Neurology, University Hospital of Copenhagen, Bispebjerg, Denmark.
  • Ferro JM; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
  • Veltkamp R; Neurology Department, Alfried-Krupp Hospital, Essen, Germany.
  • Mikulik R; International Clinical Research Center and Neurology Department, St Anne's University Hospital, Brno, Czech Republic; Medical Faculty, Masaryk University, Brno, Czech Republic.
  • De Marchis GM; Department of Neurology and Stroke Center, University Hospital of Basel and University of Basel, Basel, Switzerland.
  • Robinson T; College of Life Sciences, University of Leicester, Leicester, UK.
  • Lemmens R; Department of Neurosciences, Experimental Neurology, KU Leuven - University of Leuven, Leuven, Belgium; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium; Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
  • Stepien A; Department of Neurology, Military Institute of Medicine, Warsaw, Poland.
  • Greisenegger S; Department of Neurology, Medical University of Vienna, Vienna, Austria.
  • Roine R; Division of Clinical Neurosciences, University of Turku, Turku, Finland.
  • Csiba L; DE Clinical Center (DEKK), Health Service Units, Clinics, Department of Neurology, University of Debrecen, Debrecen, Hungary.
  • Khatri P; Department of Neurology and Rehabilitation Sciences, University of Cincinnati, Cincinnati, OH, USA.
  • Coutinho J; Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
  • Lindgren AG; Department of Clinical Sciences Lund (Neurology), Lund University, Lund, Sweden; Department of Neurology, Skåne University Hospital, Lund, Sweden.
  • Demchuk AM; Department of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Radiology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  • Colorado P; Bayer US Pharmaceuticals, Whippany, NJ, USA.
  • Kirsch B; Statistics and Data Insights, Bayer AG, Berlin, Germany.
  • Neumann C; Bayer AG, Wuppertal, Germany.
  • Heenan L; Department of Statistics, McMaster University, Population Health Research Institute, Hamilton, ON, Canada.
  • Xu L; Department of Statistics, McMaster University, Population Health Research Institute, Hamilton, ON, Canada.
  • Connolly SJ; Department of Medicine, McMaster University, Population Health Research Institute, Hamilton, ON, Canada.
  • Hart RG; Division of Neurology, McMaster University, Population Health Research Institute, Hamilton, ON, Canada.
Lancet ; 400(10357): 997-1007, 2022 09 24.
Article de En | MEDLINE | ID: mdl-36063821
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Thrombose / Encéphalopathie ischémique / Accident vasculaire cérébral / Accident vasculaire cérébral ischémique Type d'étude: Clinical_trials Limites: Aged / Female / Humans / Male Langue: En Journal: Lancet Année: 2022 Type de document: Article Pays de publication: Royaume-Uni
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Thrombose / Encéphalopathie ischémique / Accident vasculaire cérébral / Accident vasculaire cérébral ischémique Type d'étude: Clinical_trials Limites: Aged / Female / Humans / Male Langue: En Journal: Lancet Année: 2022 Type de document: Article Pays de publication: Royaume-Uni