Targeted inhibition of tumor-derived exosomes as a novel therapeutic option for cancer.
Exp Mol Med
; 54(9): 1379-1389, 2022 09.
Article
de En
| MEDLINE
| ID: mdl-36117219
ABSTRACT
Mounting evidence indicates that tumor-derived exosomes (TDEs) play critical roles in tumor development and progression by regulating components in the tumor microenvironment (TME) in an autocrine or paracrine manner. Moreover, due to their delivery of critical molecules that react to chemotherapy and immunotherapy, TDEs also contribute to tumor drug resistance and impede the effective response of antitumor immunotherapy, thereby leading to poor clinical outcomes. There is a pressing need for the inhibition or removal of TDEs to facilitate the treatment and prognosis of cancer patients. Here, in the present review, we systematically overviewed the current strategies for TDE inhibition and clearance, providing novel insights for future tumor interventions in translational medicine. Moreover, existing challenges and potential prospects for TDE-targeted cancer therapy are also discussed to bridge the gaps between progress and promising applications.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Exosomes
/
Tumeurs
Limites:
Humans
Langue:
En
Journal:
Exp Mol Med
Sujet du journal:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Année:
2022
Type de document:
Article